Prognostic impact of nodal involvement in Waldenström macroglobulinaemia

Simon Østergaard; Lars Munksgaard; Troels Hammer; Mette Ø. Pedersen; Torsten H. Nielsen; Lise Mette R. Gjerdrum

doi:10.1111/bjh.19809

Prognostic impact of nodal involvement in Waldenström macroglobulinaemia

Simon Østergaard^*, Lars Munksgaard, Troels Hammer, Mette Ø. Pedersen, Torsten H. Nielsen, Lise Mette R. Gjerdrum

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The clinical and prognostic implications of nodal involvement (NI) in Waldenström macroglobulinaemia (WM) are largely unknown. In this study, we explored the impact of NI on clinical presentation and outcome in a population-based cohort of 469 patients with WM, consecutively diagnosed between 2000 and 2022. NI was detected in 34% of patients and was associated with symptomatic disease, adverse prognostic factors, an increased risk of transformation, and lymphoma-related death. Our findings indicate that NI is of prognostic significance in WM, suggesting a need for enhanced surveillance in these patients.

Original language	English
Journal	British Journal of Haematology
Volume	205
Issue number	6
Pages (from-to)	2282-2286
Number of pages	5
ISSN	0007-1048
DOIs	https://doi.org/10.1111/bjh.19809
Publication status	Published - 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.

Keywords

extra-medullary disease
histological transformation
non-Hodgkin's lymphoma
prognosis
Waldenström's macroglobulinaemia

Access to Document

10.1111/bjh.19809Licence: CC BY-NC-ND

FulltextFinal published version, 823 KBLicence: CC BY-NC-ND

Cite this

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title = "Prognostic impact of nodal involvement in Waldenstr{\"o}m macroglobulinaemia",

abstract = "The clinical and prognostic implications of nodal involvement (NI) in Waldenstr{\"o}m macroglobulinaemia (WM) are largely unknown. In this study, we explored the impact of NI on clinical presentation and outcome in a population-based cohort of 469 patients with WM, consecutively diagnosed between 2000 and 2022. NI was detected in 34% of patients and was associated with symptomatic disease, adverse prognostic factors, an increased risk of transformation, and lymphoma-related death. Our findings indicate that NI is of prognostic significance in WM, suggesting a need for enhanced surveillance in these patients.",

keywords = "extra-medullary disease, histological transformation, non-Hodgkin's lymphoma, prognosis, Waldenstr{\"o}m's macroglobulinaemia",

author = "Simon {\O}stergaard and Lars Munksgaard and Troels Hammer and Pedersen, {Mette {\O}.} and Nielsen, {Torsten H.} and Gjerdrum, {Lise Mette R.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.",

year = "2024",

doi = "10.1111/bjh.19809",

language = "English",

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T1 - Prognostic impact of nodal involvement in Waldenström macroglobulinaemia

AU - Østergaard, Simon

AU - Munksgaard, Lars

AU - Hammer, Troels

AU - Pedersen, Mette Ø.

AU - Nielsen, Torsten H.

AU - Gjerdrum, Lise Mette R.

PY - 2024

Y1 - 2024

N2 - The clinical and prognostic implications of nodal involvement (NI) in Waldenström macroglobulinaemia (WM) are largely unknown. In this study, we explored the impact of NI on clinical presentation and outcome in a population-based cohort of 469 patients with WM, consecutively diagnosed between 2000 and 2022. NI was detected in 34% of patients and was associated with symptomatic disease, adverse prognostic factors, an increased risk of transformation, and lymphoma-related death. Our findings indicate that NI is of prognostic significance in WM, suggesting a need for enhanced surveillance in these patients.

AB - The clinical and prognostic implications of nodal involvement (NI) in Waldenström macroglobulinaemia (WM) are largely unknown. In this study, we explored the impact of NI on clinical presentation and outcome in a population-based cohort of 469 patients with WM, consecutively diagnosed between 2000 and 2022. NI was detected in 34% of patients and was associated with symptomatic disease, adverse prognostic factors, an increased risk of transformation, and lymphoma-related death. Our findings indicate that NI is of prognostic significance in WM, suggesting a need for enhanced surveillance in these patients.

KW - extra-medullary disease

KW - histological transformation

KW - non-Hodgkin's lymphoma

KW - prognosis

KW - Waldenström's macroglobulinaemia

U2 - 10.1111/bjh.19809

DO - 10.1111/bjh.19809

M3 - Journal article

C2 - 39350605

AN - SCOPUS:85205389300

SN - 0007-1048

VL - 205

SP - 2282

EP - 2286

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 6

ER -