Abstract
Background: The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma. Methods: All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index. Results: The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence-free survival. The prognostic model that agreed best with actual outcomes had a C-index of 0.76. Conclusion: Prognostic scoring models may improve individualized follow-up strategies after curatively intended treatment for patients with parotid gland carcinoma.
Original language | English |
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Journal | Head and Neck |
Volume | 43 |
Issue number | 7 |
Pages (from-to) | 2081-2090 |
Number of pages | 10 |
ISSN | 1043-3074 |
DOIs | |
Publication status | Published - Jul 2021 |
Bibliographical note
Funding Information:This study was supported by the Danish Head and Neck Cancer Group (DAHANCA) and by Open Patient data Explorative Network (OPEN), Odense University Hospital, Denmark. Grants were provided from the University of Southern Denmark, the Region of Southern Denmark, the Danish Cancer Research Fund, and the Danish Cancer Society.
Publisher Copyright:
© 2021 Wiley Periodicals LLC.
Keywords
- follow-up
- parotid gland carcinoma
- prognosis
- prognostic scoring model
- recurrence risk