Abstract
The uPA-mediated pathway of plasminogen activation is central to cancer metastasis. Whether uPA and PAI-1 are related to local recurrence, metastatic spread or both is not clear. We present a retrospective study of 429 primary breast cancer patients with a median follow-up of 5.1 years, in which the levels of uPA and PAI-1 in tumour extracts were analysed by means of an enzyme-linked immunosorbent assay. The median values of uPA and PAI-1, which were used as cut-off points, were 4.5 and 11.1 ng mg(-1) protein respectively. The levels of uPA and PAI-1 were correlated with tumour size, degree of anaplasia, steroid receptor status and number of positive nodes. Patients with high content of either uPA or PAI-1 had increased risk of relapse and death. We demonstrated an independent ability of PAI-1 to predict distant metastasis (relative risk 1.7, confidence limits 1.22 and 2.46) and that neither uPA nor PAI-1 provided any information regarding local recurrence.
Original language | English |
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Journal | British Journal of Cancer |
Volume | 77 |
Issue number | 6 |
Pages (from-to) | 932-40 |
Number of pages | 9 |
ISSN | 0007-0920 |
DOIs | |
Publication status | Published - Mar 1998 |
Keywords
- Adult
- Aged
- Breast Neoplasms/enzymology
- Carcinoma, Intraductal, Noninfiltrating/enzymology
- Cell Differentiation
- Enzyme-Linked Immunosorbent Assay
- Female
- Follow-Up Studies
- Humans
- Lymph Nodes/pathology
- Lymphatic Metastasis
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Plasminogen Activator Inhibitor 1/analysis
- Predictive Value of Tests
- Prognosis
- Receptors, Estrogen
- Receptors, Progesterone
- Risk Assessment
- Sensitivity and Specificity
- Statistics, Nonparametric
- Survival Analysis
- Time Factors
- Urokinase-Type Plasminogen Activator/analysis