Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.

Lisa Frankel, Nanna R Christoffersen, Anders Jacobsen, Morten Lindow, Anders Krogh, Anders Henrik Lund

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    1033 Citations (Scopus)

    Abstract

    MicroRNAs are emerging as important regulators of cancer-related processes. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been causally linked to cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer cells causes reduced cell growth. Using array expression analysis of MCF-7 cells depleted of miR-21, we have identified mRNA targets of mir-21 and have shown a link between miR-21 and the p53 tumor suppressor protein. We furthermore found that the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and demonstrated that PDCD4 is a functionally important target for miR-21 in breast cancer cells.
    Original languageEnglish
    JournalJournal of Biological Chemistry
    Volume283
    Issue number2
    Pages (from-to)1026-33
    Number of pages7
    ISSN0021-9258
    DOIs
    Publication statusPublished - 2008

    Bibliographical note

    Keywords: Apoptosis; Apoptosis Regulatory Proteins; Base Sequence; Breast Neoplasms; Cell Division; Cell Line, Tumor; Female; Humans; Kinetics; MicroRNAs; RNA, Neoplasm; RNA-Binding Proteins

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