Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.

Lisa Frankel; Nanna R Christoffersen; Anders Jacobsen; Morten Lindow; Anders Krogh; Anders Henrik Lund

doi:10.1074/jbc.M707224200

Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.

Lisa Frankel, Nanna R Christoffersen, Anders Jacobsen, Morten Lindow, Anders Krogh, Anders Henrik Lund

Research output: Contribution to journal › Journal article › Research › peer-review

1031 Citations (Scopus)

Abstract

MicroRNAs are emerging as important regulators of cancer-related processes. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been causally linked to cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer cells causes reduced cell growth. Using array expression analysis of MCF-7 cells depleted of miR-21, we have identified mRNA targets of mir-21 and have shown a link between miR-21 and the p53 tumor suppressor protein. We furthermore found that the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and demonstrated that PDCD4 is a functionally important target for miR-21 in breast cancer cells.

Original language	English
Journal	Journal of Biological Chemistry
Volume	283
Issue number	2
Pages (from-to)	1026-33
Number of pages	7
ISSN	0021-9258
DOIs	https://doi.org/10.1074/jbc.M707224200
Publication status	Published - 2008

Bibliographical note

Keywords: Apoptosis; Apoptosis Regulatory Proteins; Base Sequence; Breast Neoplasms; Cell Division; Cell Line, Tumor; Female; Humans; Kinetics; MicroRNAs; RNA, Neoplasm; RNA-Binding Proteins

Access to Document

10.1074/jbc.M707224200

Cite this

Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. / Frankel, Lisa; Christoffersen, Nanna R; Jacobsen, Anders; Lindow, Morten; Krogh, Anders; Lund, Anders Henrik.

In: Journal of Biological Chemistry, Vol. 283, No. 2, 2008, p. 1026-33.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.",

abstract = "MicroRNAs are emerging as important regulators of cancer-related processes. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been causally linked to cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer cells causes reduced cell growth. Using array expression analysis of MCF-7 cells depleted of miR-21, we have identified mRNA targets of mir-21 and have shown a link between miR-21 and the p53 tumor suppressor protein. We furthermore found that the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and demonstrated that PDCD4 is a functionally important target for miR-21 in breast cancer cells.",

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note = "Keywords: Apoptosis; Apoptosis Regulatory Proteins; Base Sequence; Breast Neoplasms; Cell Division; Cell Line, Tumor; Female; Humans; Kinetics; MicroRNAs; RNA, Neoplasm; RNA-Binding Proteins",

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AU - Lindow, Morten

AU - Krogh, Anders

AU - Lund, Anders Henrik

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AB - MicroRNAs are emerging as important regulators of cancer-related processes. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been causally linked to cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer cells causes reduced cell growth. Using array expression analysis of MCF-7 cells depleted of miR-21, we have identified mRNA targets of mir-21 and have shown a link between miR-21 and the p53 tumor suppressor protein. We furthermore found that the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and demonstrated that PDCD4 is a functionally important target for miR-21 in breast cancer cells.

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