Programming strategy for efficient modeling of dynamics in a population of heterogeneous cells

Bjørn Olav Hald; Morten Hendriksen; Preben Graae Sørensen

doi:10.1093/bioinformatics/btt132

Programming strategy for efficient modeling of dynamics in a population of heterogeneous cells

Bjørn Olav Hald, Morten Hendriksen, Preben Graae Sørensen

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Abstract

Heterogeneity is a ubiquitous property of biological systems. Even in a genetically identical population of a single cell type, cell-to-cell differences are observed. Although the functional behavior of a given population is generally robust, the consequences of heterogeneity are fairly unpredictable. In heterogeneous populations, synchronization of events becomes a cardinal problem-particularly for phase coherence in oscillating systems.

Original language	English
Journal	Bioinformatics
Volume	29
Issue number	10
Pages (from-to)	1292-1298
Number of pages	7
ISSN	1367-4803
DOIs	https://doi.org/10.1093/bioinformatics/btt132
Publication status	Published - 2013

Keywords

Faculty of Health and Medical Sciences

Access to Document

10.1093/bioinformatics/btt132

Cite this

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title = "Programming strategy for efficient modeling of dynamics in a population of heterogeneous cells",

abstract = "Heterogeneity is a ubiquitous property of biological systems. Even in a genetically identical population of a single cell type, cell-to-cell differences are observed. Although the functional behavior of a given population is generally robust, the consequences of heterogeneity are fairly unpredictable. In heterogeneous populations, synchronization of events becomes a cardinal problem-particularly for phase coherence in oscillating systems.",

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AU - Hald, Bjørn Olav

AU - Hendriksen, Morten

AU - Sørensen, Preben Graae

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N2 - Heterogeneity is a ubiquitous property of biological systems. Even in a genetically identical population of a single cell type, cell-to-cell differences are observed. Although the functional behavior of a given population is generally robust, the consequences of heterogeneity are fairly unpredictable. In heterogeneous populations, synchronization of events becomes a cardinal problem-particularly for phase coherence in oscillating systems.

AB - Heterogeneity is a ubiquitous property of biological systems. Even in a genetically identical population of a single cell type, cell-to-cell differences are observed. Although the functional behavior of a given population is generally robust, the consequences of heterogeneity are fairly unpredictable. In heterogeneous populations, synchronization of events becomes a cardinal problem-particularly for phase coherence in oscillating systems.

KW - Faculty of Health and Medical Sciences

U2 - 10.1093/bioinformatics/btt132

DO - 10.1093/bioinformatics/btt132

M3 - Journal article

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JO - Computer Applications in the Biosciences

JF - Computer Applications in the Biosciences

SN - 1471-2105

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