Prolonged submaximal eccentric exercise is associated with increased levels of plasma IL-6

    Research output: Contribution to journalJournal articleResearchpeer-review

    102 Citations (Scopus)

    Abstract

    To study the relationship between exercise-related muscle proteolysis and the cytokine response, a prolonged eccentric exercise model of one leg was used. Subjects performed two trials [a branched-chain amino acid (BCAA) supplementation and a control trial]. The release of amino acids from muscle during and after the eccentric exercise was decreased in the BCAA trial, suggesting a suppression of net muscle protein degradation. The plasma concentrations of interleukin (IL)-6 increased from 0.75 +/- 0.19 (preexercise) to 5.02 +/- 0.96 pg/ml (2 h postexercise) in the control trial and in the BCAA supplementation trial from 1.07 +/- 0.41 to 4.15 +/- 1.21 pg/ml. Eccentric exercise had no effect on the concentrations of neutrophils, lymphocytes, CD16+/CD56+, CD4+, CD8+, CD14+/CD38+, lymphocyte proliferative response, or cytotoxic activities. BCAA supplementation reduced the concentration of CD14+/CD38+ cells. This study shows that the concentration of IL-6 in plasma is increased after prolonged eccentric exercise and suggests that the cytokine response is independent of the muscle proteolysis that occur during exercise.

    Original languageEnglish
    JournalAmerican Journal of Physiology: Endocrinology and Metabolism
    Volume273
    Issue number1
    Pages (from-to)E85-E91
    Number of pages7
    ISSN0193-1849
    Publication statusPublished - 1997

    Keywords

    • Adult
    • Amino Acids
    • Amino Acids, Branched-Chain
    • Analysis of Variance
    • Cytokines
    • Epinephrine
    • Exercise
    • Exercise Test
    • Food, Fortified
    • Humans
    • Interleukin-1
    • Interleukin-6
    • Killer Cells, Natural
    • Leukocyte Count
    • Lymphocyte Activation
    • Lymphocyte Count
    • Male
    • Muscle, Skeletal
    • Norepinephrine
    • Reference Values
    • Time Factors
    • Tumor Necrosis Factor-alpha

    Cite this