Abstract
To study the relationship between exercise-related muscle proteolysis and the cytokine response, a prolonged eccentric exercise model of one leg was used. Subjects performed two trials [a branched-chain amino acid (BCAA) supplementation and a control trial]. The release of amino acids from muscle during and after the eccentric exercise was decreased in the BCAA trial, suggesting a suppression of net muscle protein degradation. The plasma concentrations of interleukin (IL)-6 increased from 0.75 +/- 0.19 (preexercise) to 5.02 +/- 0.96 pg/ml (2 h postexercise) in the control trial and in the BCAA supplementation trial from 1.07 +/- 0.41 to 4.15 +/- 1.21 pg/ml. Eccentric exercise had no effect on the concentrations of neutrophils, lymphocytes, CD16+/CD56+, CD4+, CD8+, CD14+/CD38+, lymphocyte proliferative response, or cytotoxic activities. BCAA supplementation reduced the concentration of CD14+/CD38+ cells. This study shows that the concentration of IL-6 in plasma is increased after prolonged eccentric exercise and suggests that the cytokine response is independent of the muscle proteolysis that occur during exercise.
Original language | English |
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Journal | American Journal of Physiology: Endocrinology and Metabolism |
Volume | 273 |
Issue number | 1 |
Pages (from-to) | E85-E91 |
Number of pages | 7 |
ISSN | 0193-1849 |
Publication status | Published - 1997 |
Keywords
- Adult
- Amino Acids
- Amino Acids, Branched-Chain
- Analysis of Variance
- Cytokines
- Epinephrine
- Exercise
- Exercise Test
- Food, Fortified
- Humans
- Interleukin-1
- Interleukin-6
- Killer Cells, Natural
- Leukocyte Count
- Lymphocyte Activation
- Lymphocyte Count
- Male
- Muscle, Skeletal
- Norepinephrine
- Reference Values
- Time Factors
- Tumor Necrosis Factor-alpha