Protective succinate-SUCNR1 metabolic stress signaling gone bad

Sally Winther; Mette Trauelsen; Thue W. Schwartz

doi:10.1016/j.cmet.2021.06.009

Protective succinate-SUCNR1 metabolic stress signaling gone bad

Sally Winther, Mette Trauelsen, Thue W. Schwartz^*

^*Corresponding author for this work

Schwartz Group

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Abstract

The TCA cycle metabolite succinate functions as an intra- and extracellular signal of metabolic stress. Based on the phenotype of UCP-1-deficient mice, Mills et al. (2021) now report in Nature Metabolism that accumulation of extracellular succinate due to impaired elimination in thermogenic fat drives liver inflammation and fibrosis through the succinate receptor SUCNR1.

Original language	English
Journal	Cell Metabolism
Volume	33
Issue number	7
Pages (from-to)	1276-1278
Number of pages	3
ISSN	1550-4131
DOIs	https://doi.org/10.1016/j.cmet.2021.06.009
Publication status	Published - 2021

Keywords

EXTRACELLULAR SUCCINATE
MACROPHAGES

Access to Document

10.1016/j.cmet.2021.06.009

Cite this

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title = "Protective succinate-SUCNR1 metabolic stress signaling gone bad",

abstract = "The TCA cycle metabolite succinate functions as an intra- and extracellular signal of metabolic stress. Based on the phenotype of UCP-1-deficient mice, Mills et al. (2021) now report in Nature Metabolism that accumulation of extracellular succinate due to impaired elimination in thermogenic fat drives liver inflammation and fibrosis through the succinate receptor SUCNR1.",

keywords = "EXTRACELLULAR SUCCINATE, MACROPHAGES",

author = "Sally Winther and Mette Trauelsen and Schwartz, {Thue W.}",

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T1 - Protective succinate-SUCNR1 metabolic stress signaling gone bad

AU - Winther, Sally

AU - Trauelsen, Mette

AU - Schwartz, Thue W.

PY - 2021

Y1 - 2021

N2 - The TCA cycle metabolite succinate functions as an intra- and extracellular signal of metabolic stress. Based on the phenotype of UCP-1-deficient mice, Mills et al. (2021) now report in Nature Metabolism that accumulation of extracellular succinate due to impaired elimination in thermogenic fat drives liver inflammation and fibrosis through the succinate receptor SUCNR1.

AB - The TCA cycle metabolite succinate functions as an intra- and extracellular signal of metabolic stress. Based on the phenotype of UCP-1-deficient mice, Mills et al. (2021) now report in Nature Metabolism that accumulation of extracellular succinate due to impaired elimination in thermogenic fat drives liver inflammation and fibrosis through the succinate receptor SUCNR1.

KW - EXTRACELLULAR SUCCINATE

KW - MACROPHAGES

U2 - 10.1016/j.cmet.2021.06.009

DO - 10.1016/j.cmet.2021.06.009

M3 - Journal article

C2 - 34233171

VL - 33

SP - 1276

EP - 1278

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 7

ER -