Abstract
Network-based approaches may leverage genome-wide association (GWA) analysis by testing for the aggregate association across several pathway members. We aimed to examine if networks of genes that represent experimentally determined protein-protein interactions (PPIs) are enriched in genes associated with risk of coronary heart disease (CHD).
Original language | English |
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Journal | Circulation: Cardiovascular Genetics |
Volume | 4 |
Issue number | 5 |
Pages (from-to) | 549-56 |
Number of pages | 8 |
ISSN | 1942-325X |
DOIs | |
Publication status | Published - 2011 |
Keywords
- Adult
- Aged
- Animals
- Blood Pressure
- Case-Control Studies
- Coronary Disease
- Female
- Genetic Loci
- Genome-Wide Association Study
- Genotype
- Humans
- Incidence
- Male
- Mice
- Mice, Knockout
- Middle Aged
- Polymorphism, Single Nucleotide
- Protein Interaction Mapping
- Receptors, Adrenergic, beta-1
- Risk Factors