Protein interaction-based genome-wide analysis of incident coronary heart disease

Majken K Jensen, Tune H Pers, Piotr Dworzynski, Cynthia J Girman, Søren Brunak, Eric B Rimm

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54 Citations (Scopus)

Abstract

Network-based approaches may leverage genome-wide association (GWA) analysis by testing for the aggregate association across several pathway members. We aimed to examine if networks of genes that represent experimentally determined protein-protein interactions (PPIs) are enriched in genes associated with risk of coronary heart disease (CHD).
Original languageEnglish
JournalCirculation: Cardiovascular Genetics
Volume4
Issue number5
Pages (from-to)549-56
Number of pages8
ISSN1942-325X
DOIs
Publication statusPublished - 2011

Keywords

  • Adult
  • Aged
  • Animals
  • Blood Pressure
  • Case-Control Studies
  • Coronary Disease
  • Female
  • Genetic Loci
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Incidence
  • Male
  • Mice
  • Mice, Knockout
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Protein Interaction Mapping
  • Receptors, Adrenergic, beta-1
  • Risk Factors

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