Quantifying mediating effects of endogenous estrogen and insulin in the relation between obesity, alcohol consumption, and breast cancer

Ulla A Hvidtfeldt; Marc J Gunter; Theis Lange; Rowan T Chlebowski; Dorothy Lane; Ghada N Farhat; Matthew S Freiberg; Niels Keiding; Jennifer S Lee; Ross Prentice; Anne Tjønneland; Mara Z Vitolins; Silvia Wassertheil-Smoller; Howard D Strickler; Naja Hulvej Rod

doi:10.1158/1055-9965.EPI-12-0310

Quantifying mediating effects of endogenous estrogen and insulin in the relation between obesity, alcohol consumption, and breast cancer

Ulla A Hvidtfeldt, Marc J Gunter, Theis Lange, Rowan T Chlebowski, Dorothy Lane, Ghada N Farhat, Matthew S Freiberg, Niels Keiding, Jennifer S Lee, Ross Prentice, Anne Tjønneland, Mara Z Vitolins, Silvia Wassertheil-Smoller, Howard D Strickler, Naja Hulvej Rod

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

Abstract

Increased exposure to endogenous estrogen and/or insulin may partly explain the relationship of obesity, physical inactivity, and alcohol consumption and postmenopausal breast cancer. However, these potential mediating effects have not been formally quantified in a survival analysis setting.

Original language	English
Journal	Cancer Epidemiology, Biomarkers & Prevention
Volume	21
Issue number	7
Pages (from-to)	1203-12
Number of pages	10
ISSN	1055-9965
DOIs	https://doi.org/10.1158/1055-9965.EPI-12-0310
Publication status	Published - 2012

Keywords

Aged
Alcohol Drinking
Body Mass Index
Breast Neoplasms
Case-Control Studies
Estrogens
Female
Follow-Up Studies
Humans
Hypoglycemic Agents
Incidence
Insulin
Male
Middle Aged
Obesity
Prognosis
United States
Women's Health

Access to Document

10.1158/1055-9965.EPI-12-0310

Cite this

Hvidtfeldt, U. A., Gunter, M. J., Lange, T., Chlebowski, R. T., Lane, D., Farhat, G. N., Freiberg, M. S., Keiding, N., Lee, J. S., Prentice, R., Tjønneland, A., Vitolins, M. Z., Wassertheil-Smoller, S., Strickler, H. D., & Rod, N. H. (2012). Quantifying mediating effects of endogenous estrogen and insulin in the relation between obesity, alcohol consumption, and breast cancer. Cancer Epidemiology, Biomarkers & Prevention, 21(7), 1203-12. https://doi.org/10.1158/1055-9965.EPI-12-0310

Quantifying mediating effects of endogenous estrogen and insulin in the relation between obesity, alcohol consumption, and breast cancer. / Hvidtfeldt, Ulla A; Gunter, Marc J; Lange, Theis; Chlebowski, Rowan T; Lane, Dorothy; Farhat, Ghada N; Freiberg, Matthew S; Keiding, Niels; Lee, Jennifer S; Prentice, Ross; Tjønneland, Anne; Vitolins, Mara Z; Wassertheil-Smoller, Silvia; Strickler, Howard D; Rod, Naja Hulvej.

In: Cancer Epidemiology, Biomarkers & Prevention, Vol. 21, No. 7, 2012, p. 1203-12.

Research output: Contribution to journal › Journal article › Research › peer-review

Hvidtfeldt, UA, Gunter, MJ, Lange, T, Chlebowski, RT, Lane, D, Farhat, GN, Freiberg, MS, Keiding, N, Lee, JS, Prentice, R, Tjønneland, A, Vitolins, MZ, Wassertheil-Smoller, S, Strickler, HD & Rod, NH 2012, 'Quantifying mediating effects of endogenous estrogen and insulin in the relation between obesity, alcohol consumption, and breast cancer', Cancer Epidemiology, Biomarkers & Prevention, vol. 21, no. 7, pp. 1203-12. https://doi.org/10.1158/1055-9965.EPI-12-0310

Hvidtfeldt, Ulla A ; Gunter, Marc J ; Lange, Theis ; Chlebowski, Rowan T ; Lane, Dorothy ; Farhat, Ghada N ; Freiberg, Matthew S ; Keiding, Niels ; Lee, Jennifer S ; Prentice, Ross ; Tjønneland, Anne ; Vitolins, Mara Z ; Wassertheil-Smoller, Silvia ; Strickler, Howard D ; Rod, Naja Hulvej. / Quantifying mediating effects of endogenous estrogen and insulin in the relation between obesity, alcohol consumption, and breast cancer. In: Cancer Epidemiology, Biomarkers & Prevention. 2012 ; Vol. 21, No. 7. pp. 1203-12.

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AU - Lane, Dorothy

AU - Farhat, Ghada N

AU - Freiberg, Matthew S

AU - Keiding, Niels

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AU - Tjønneland, Anne

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KW - Follow-Up Studies

KW - Humans

KW - Hypoglycemic Agents

KW - Incidence

KW - Insulin

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KW - Middle Aged

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