TY - JOUR
T1 - (-)-(R)-5,5-dimethylmorpholinyl-2-acetic acid ethyl ester hydrochloride, C10H20NO3+.Cl-
AU - Frydenvang, Karla
AU - Enna, Sam J.
AU - Krogsgaard-Larsen, Povl
PY - 1997/8/15
Y1 - 1997/8/15
N2 - One of the enantiomers of 5,5-dimethylmorpholinyl-2-acetic acid is observed to be a GABAB receptor antagonist. The absolute configuration of the inactive enantiomer is found to be the R configuration. The morpholine ring adopts a chair conformation with the acetic acid moiety in an equatorial position. In the crystal packing, hydrogen bonds are observed between the ammonium group and the chloride ions.
AB - One of the enantiomers of 5,5-dimethylmorpholinyl-2-acetic acid is observed to be a GABAB receptor antagonist. The absolute configuration of the inactive enantiomer is found to be the R configuration. The morpholine ring adopts a chair conformation with the acetic acid moiety in an equatorial position. In the crystal packing, hydrogen bonds are observed between the ammonium group and the chloride ions.
UR - http://www.scopus.com/inward/record.url?scp=0031213330&partnerID=8YFLogxK
U2 - 10.1107/S0108270197004290
DO - 10.1107/S0108270197004290
M3 - Journal article
AN - SCOPUS:0031213330
VL - 53
SP - 1088
EP - 1091
JO - Acta crystallographica. Section C, Structural chemistry
JF - Acta crystallographica. Section C, Structural chemistry
SN - 2053-2296
IS - 8
ER -