(-)-(R)-5,5-dimethylmorpholinyl-2-acetic acid ethyl ester hydrochloride, C10H20NO3+.Cl-

Karla Frydenvang; Sam J. Enna; Povl Krogsgaard-Larsen

doi:10.1107/S0108270197004290

(-)-(R)-5,5-dimethylmorpholinyl-2-acetic acid ethyl ester hydrochloride, C₁₀H₂₀NO₃⁺.Cl^-

Karla Frydenvang^*, Sam J. Enna, Povl Krogsgaard-Larsen

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Abstract

One of the enantiomers of 5,5-dimethylmorpholinyl-2-acetic acid is observed to be a GABA_B receptor antagonist. The absolute configuration of the inactive enantiomer is found to be the R configuration. The morpholine ring adopts a chair conformation with the acetic acid moiety in an equatorial position. In the crystal packing, hydrogen bonds are observed between the ammonium group and the chloride ions.

Original language	English
Journal	Acta Crystallographica Section C: Crystal Structure Communications
Volume	53
Issue number	8
Pages (from-to)	1088-1091
Number of pages	4
ISSN	0108-2701
DOIs	https://doi.org/10.1107/S0108270197004290
Publication status	Published - 15 Aug 1997

Access to Document

10.1107/S0108270197004290

Library access?

Check availability at the Royal Danish Library

Cite this

@article{3eb95662f16048bd86c1deada625b1e9,

title = "(-)-(R)-5,5-dimethylmorpholinyl-2-acetic acid ethyl ester hydrochloride, C10H20NO3+.Cl-",

abstract = "One of the enantiomers of 5,5-dimethylmorpholinyl-2-acetic acid is observed to be a GABAB receptor antagonist. The absolute configuration of the inactive enantiomer is found to be the R configuration. The morpholine ring adopts a chair conformation with the acetic acid moiety in an equatorial position. In the crystal packing, hydrogen bonds are observed between the ammonium group and the chloride ions.",

author = "Karla Frydenvang and Enna, {Sam J.} and Povl Krogsgaard-Larsen",

year = "1997",

month = aug,

day = "15",

doi = "10.1107/S0108270197004290",

language = "English",

volume = "53",

pages = "1088--1091",

journal = "Acta Crystallographica Section C: Crystal Structure Communications",

issn = "0108-2701",

publisher = "Wiley",

number = "8",

}

TY - JOUR

T1 - (-)-(R)-5,5-dimethylmorpholinyl-2-acetic acid ethyl ester hydrochloride, C10H20NO3+.Cl-

AU - Frydenvang, Karla

AU - Enna, Sam J.

AU - Krogsgaard-Larsen, Povl

PY - 1997/8/15

Y1 - 1997/8/15

N2 - One of the enantiomers of 5,5-dimethylmorpholinyl-2-acetic acid is observed to be a GABAB receptor antagonist. The absolute configuration of the inactive enantiomer is found to be the R configuration. The morpholine ring adopts a chair conformation with the acetic acid moiety in an equatorial position. In the crystal packing, hydrogen bonds are observed between the ammonium group and the chloride ions.

AB - One of the enantiomers of 5,5-dimethylmorpholinyl-2-acetic acid is observed to be a GABAB receptor antagonist. The absolute configuration of the inactive enantiomer is found to be the R configuration. The morpholine ring adopts a chair conformation with the acetic acid moiety in an equatorial position. In the crystal packing, hydrogen bonds are observed between the ammonium group and the chloride ions.

UR - http://www.scopus.com/inward/record.url?scp=0031213330&partnerID=8YFLogxK

U2 - 10.1107/S0108270197004290

DO - 10.1107/S0108270197004290

M3 - Journal article

AN - SCOPUS:0031213330

SN - 0108-2701

VL - 53

SP - 1088

EP - 1091

JO - Acta Crystallographica Section C: Crystal Structure Communications

JF - Acta Crystallographica Section C: Crystal Structure Communications

IS - 8