R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse

Claus J Loland; Maddalena Mereu; Oluyomi M Okunola; Jianjing Cao; Thomas E Prisinzano; Sonia Mazier; Theresa Kopajtic; Lei Shi; Jonathan L Katz; Gianluigi Tanda; Amy Hauck Newman

doi:10.1016/j.biopsych.2012.03.022

R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse

Claus J Loland, Maddalena Mereu, Oluyomi M Okunola, Jianjing Cao, Thomas E Prisinzano, Sonia Mazier, Theresa Kopajtic, Lei Shi, Jonathan L Katz, Gianluigi Tanda, Amy Hauck Newman

Eyepath Lab

Research output: Contribution to journal › Journal article › Research › peer-review

93 Citations (Scopus)

Abstract

(±)-Modafinil has piqued interest as a treatment for attention-deficit/hyperactivity disorder and stimulant dependence. The R-enantiomer of modafinil might have unique pharmacological properties that should be further investigated.

Original language	English
Journal	Biological Psychiatry
Volume	72
Issue number	5
Pages (from-to)	405-13
Number of pages	9
ISSN	0006-3223
DOIs	https://doi.org/10.1016/j.biopsych.2012.03.022
Publication status	Published - Sep 2012

Keywords

Animals
Benzhydryl Compounds
Central Nervous System Stimulants
Cocaine
Dopamine
Dopamine Plasma Membrane Transport Proteins
Dopamine Uptake Inhibitors
Humans
Male
Mice
Microdialysis
Nucleus Accumbens
Protein Binding
Substance-Related Disorders

Access to Document

10.1016/j.biopsych.2012.03.022

Cite this

R-modafinil (armodafinil) : a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse. / Loland, Claus J; Mereu, Maddalena; Okunola, Oluyomi M; Cao, Jianjing; Prisinzano, Thomas E; Mazier, Sonia; Kopajtic, Theresa; Shi, Lei; Katz, Jonathan L; Tanda, Gianluigi; Newman, Amy Hauck.

In: Biological Psychiatry, Vol. 72, No. 5, 09.2012, p. 405-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Loland, Claus J ; Mereu, Maddalena ; Okunola, Oluyomi M ; Cao, Jianjing ; Prisinzano, Thomas E ; Mazier, Sonia ; Kopajtic, Theresa ; Shi, Lei ; Katz, Jonathan L ; Tanda, Gianluigi ; Newman, Amy Hauck. / R-modafinil (armodafinil) : a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse. In: Biological Psychiatry. 2012 ; Vol. 72, No. 5. pp. 405-13.

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keywords = "Animals, Benzhydryl Compounds, Central Nervous System Stimulants, Cocaine, Dopamine, Dopamine Plasma Membrane Transport Proteins, Dopamine Uptake Inhibitors, Humans, Male, Mice, Microdialysis, Nucleus Accumbens, Protein Binding, Substance-Related Disorders",

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AU - Okunola, Oluyomi M

AU - Cao, Jianjing

AU - Prisinzano, Thomas E

AU - Mazier, Sonia

AU - Kopajtic, Theresa

AU - Shi, Lei

AU - Katz, Jonathan L

AU - Tanda, Gianluigi

AU - Newman, Amy Hauck

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KW - Central Nervous System Stimulants

KW - Cocaine

KW - Dopamine

KW - Dopamine Plasma Membrane Transport Proteins

KW - Dopamine Uptake Inhibitors

KW - Humans

KW - Male

KW - Mice

KW - Microdialysis

KW - Nucleus Accumbens

KW - Protein Binding

KW - Substance-Related Disorders

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DO - 10.1016/j.biopsych.2012.03.022

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JO - Biological Psychiatry

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