Radiosynthesis and ex vivo evaluation of (R)-(-)-2-chloro-N-[1-11C-propyl]n-propylnorapomorphine

Mikael Palner; Patrick McCormick; Nicolas Gillings; Mikael Begtrup; Alan A Wilson; Gitte M Knudsen

doi:10.1016/j.nucmedbio.2009.08.005

Radiosynthesis and ex vivo evaluation of (R)-(-)-2-chloro-N-[1-11C-propyl]n-propylnorapomorphine

Mikael Palner, Patrick McCormick, Nicolas Gillings, Mikael Begtrup, Alan A Wilson, Gitte M Knudsen

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Abstract

Several dopamine D(2) agonist radioligands have been used with positron emission tomography (PET), including [(11)C-]-(-)-MNPA, [(11)C-]-(-)-NPA and [(11)C]-(+)-PHNO. These radioligands are considered particularly powerful for detection of endogenous dopamine release, but they either provide PET brain images with limited contrast or have affinity for both D(2) and D(3) receptors. We here present the carbon-11 radiolabeling and ex vivo evaluation of 2-Cl-(-)-NPA, a novel PET-tracer candidate with high in vitro D(2)/D(3) selectivity.

Original language	English
Journal	Nuclear Medicine and Biology
Volume	37
Issue number	1
Pages (from-to)	35-40
Number of pages	6
ISSN	0969-8051
DOIs	https://doi.org/10.1016/j.nucmedbio.2009.08.005
Publication status	Published - 1 Jan 2010

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title = "Radiosynthesis and ex vivo evaluation of (R)-(-)-2-chloro-N-[1-11C-propyl]n-propylnorapomorphine",

abstract = "Several dopamine D(2) agonist radioligands have been used with positron emission tomography (PET), including [(11)C-]-(-)-MNPA, [(11)C-]-(-)-NPA and [(11)C]-(+)-PHNO. These radioligands are considered particularly powerful for detection of endogenous dopamine release, but they either provide PET brain images with limited contrast or have affinity for both D(2) and D(3) receptors. We here present the carbon-11 radiolabeling and ex vivo evaluation of 2-Cl-(-)-NPA, a novel PET-tracer candidate with high in vitro D(2)/D(3) selectivity.",

author = "Mikael Palner and Patrick McCormick and Nicolas Gillings and Mikael Begtrup and Wilson, {Alan A} and Knudsen, {Gitte M}",

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T1 - Radiosynthesis and ex vivo evaluation of (R)-(-)-2-chloro-N-[1-11C-propyl]n-propylnorapomorphine

AU - Palner, Mikael

AU - McCormick, Patrick

AU - Gillings, Nicolas

AU - Begtrup, Mikael

AU - Wilson, Alan A

AU - Knudsen, Gitte M

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Several dopamine D(2) agonist radioligands have been used with positron emission tomography (PET), including [(11)C-]-(-)-MNPA, [(11)C-]-(-)-NPA and [(11)C]-(+)-PHNO. These radioligands are considered particularly powerful for detection of endogenous dopamine release, but they either provide PET brain images with limited contrast or have affinity for both D(2) and D(3) receptors. We here present the carbon-11 radiolabeling and ex vivo evaluation of 2-Cl-(-)-NPA, a novel PET-tracer candidate with high in vitro D(2)/D(3) selectivity.

AB - Several dopamine D(2) agonist radioligands have been used with positron emission tomography (PET), including [(11)C-]-(-)-MNPA, [(11)C-]-(-)-NPA and [(11)C]-(+)-PHNO. These radioligands are considered particularly powerful for detection of endogenous dopamine release, but they either provide PET brain images with limited contrast or have affinity for both D(2) and D(3) receptors. We here present the carbon-11 radiolabeling and ex vivo evaluation of 2-Cl-(-)-NPA, a novel PET-tracer candidate with high in vitro D(2)/D(3) selectivity.

U2 - 10.1016/j.nucmedbio.2009.08.005

DO - 10.1016/j.nucmedbio.2009.08.005

M3 - Journal article

SN - 0969-8051

VL - 37

SP - 35

EP - 40

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

IS - 1

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