Rapid Prototyping of Miniaturized Powder Mixing Geometries

Rasmus Svane, Troels Pedersen, Cosima Hirschberg, Jukka Rantanen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

2 Citations (Scopus)
36 Downloads (Pure)

Abstract

Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel mixing principles applicable for continuous manufacturing. However, these innovative ideas based on simulations need experimental validation. The use of rapid prototyping based on additive manufacturing opens a possibility to evaluate these ideas at a low cost. In this study, a novel powder mixing geometry was prototyped using additive manufacturing and further, interfaced with an in-line near-IR spectrometer allowing for investigating the residence time distribution (RTD) in this geometry.

Original languageEnglish
JournalJournal of Pharmaceutical Sciences
Volume110
Issue number7
Pages (from-to)2625-2628
ISSN0022-3549
DOIs
Publication statusPublished - 2021

Bibliographical note

Publisher Copyright:
© 2021 The Authors

Keywords

  • 3D printing
  • Continuous manufacturing
  • Inline monitoring
  • Multivariate data analysis
  • Process analytical technology (PAT)
  • Residence time distribution (RTD)

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