TY - JOUR
T1 - Recent advances in precision nutrition and cardiometabolic diseases
AU - Martínez-González, Miguel A
AU - Planes, Francisco J
AU - Ruiz-Canela, Miguel
AU - Toledo, Estefanía
AU - Estruch, Ramón
AU - Salas-Salvadó, Jordi
AU - Valdés-Más, Rafael
AU - Mena, Pedro
AU - Castañer, Olga
AU - Fitó, Montse
AU - Clish, Clary
AU - Landberg, Rikard
AU - Wittenbecher, Clemens
AU - Liang, Liming
AU - Guasch-Ferré, Marta
AU - Lamuela-Raventós, Rosa M
AU - Wang, Dong D
AU - Forouhi, Nita
AU - Razquin, Cristina
AU - B Hu, Frank
N1 - Copyright © 2024 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.
PY - 2024
Y1 - 2024
N2 - A growing body of research on nutrition omics has led to recent advances in cardiovascular disease epidemiology and prevention. Within the PREDIMED trial, significant associations between diet-related metabolites and cardiovascular disease were identified, which were subsequently replicated in independent cohorts. Some notable metabolites identified include plasma levels of ceramides, acyl-carnitines, branched-chain amino acids, tryptophan, urea cycle pathways, and the lipidome. These metabolites and their associated pathways have been associated with incidence of both cardiovascular disease and type 2 diabetes. Future directions in precision nutrition research include: a) developing more robust multimetabolomic scores to predict long-term risk of cardiovascular disease and mortality; b) incorporating more diverse populations and a broader range of dietary patterns; and c) conducting more translational research to bridge the gap between precision nutrition studies and clinical applications.
AB - A growing body of research on nutrition omics has led to recent advances in cardiovascular disease epidemiology and prevention. Within the PREDIMED trial, significant associations between diet-related metabolites and cardiovascular disease were identified, which were subsequently replicated in independent cohorts. Some notable metabolites identified include plasma levels of ceramides, acyl-carnitines, branched-chain amino acids, tryptophan, urea cycle pathways, and the lipidome. These metabolites and their associated pathways have been associated with incidence of both cardiovascular disease and type 2 diabetes. Future directions in precision nutrition research include: a) developing more robust multimetabolomic scores to predict long-term risk of cardiovascular disease and mortality; b) incorporating more diverse populations and a broader range of dietary patterns; and c) conducting more translational research to bridge the gap between precision nutrition studies and clinical applications.
U2 - 10.1016/j.rec.2024.09.003
DO - 10.1016/j.rec.2024.09.003
M3 - Review
C2 - 39357800
JO - Revista espanola de cardiologia (English ed.)
JF - Revista espanola de cardiologia (English ed.)
SN - 1885-5857
ER -