Recent advances in precision nutrition and cardiometabolic diseases

Miguel A Martínez-González*, Francisco J Planes, Miguel Ruiz-Canela, Estefanía Toledo, Ramón Estruch, Jordi Salas-Salvadó, Rafael Valdés-Más, Pedro Mena, Olga Castañer, Montse Fitó, Clary Clish, Rikard Landberg, Clemens Wittenbecher, Liming Liang, Marta Guasch-Ferré, Rosa M Lamuela-Raventós, Dong D Wang, Nita Forouhi, Cristina Razquin, Frank B Hu

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

Abstract

A growing body of research on nutrition omics has led to recent advances in cardiovascular disease epidemiology and prevention. Within the PREDIMED trial, significant associations between diet-related metabolites and cardiovascular disease were identified, which were subsequently replicated in independent cohorts. Some notable metabolites identified include plasma levels of ceramides, acyl-carnitines, branched-chain amino acids, tryptophan, urea cycle pathways, and the lipidome. These metabolites and their associated pathways have been associated with incidence of both cardiovascular disease and type 2 diabetes. Future directions in precision nutrition research include: a) developing more robust multimetabolomic scores to predict long-term risk of cardiovascular disease and mortality; b) incorporating more diverse populations and a broader range of dietary patterns; and c) conducting more translational research to bridge the gap between precision nutrition studies and clinical applications.

Original languageEnglish
JournalRevista espanola de cardiologia (English ed.)
ISSN1885-5857
DOIs
Publication statusE-pub ahead of print - 2024

Bibliographical note

Copyright © 2024 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

Cite this