Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe

Giulia Veronesi; David R Baldwin; Claudia I Henschke; Simone Ghislandi; Sergio Iavicoli; Matthijs Oudkerk; Harry J De Koning; Joseph Shemesh; John K Field; Javier J Zulueta; Denis Horgan; Lucia Fiestas Navarrete; Maurizio Valentino Infante; Pierluigi Novellis; Rachael L Murray; Nir Peled; Cristiano Rampinelli; Gaetano Rocco; Witold Rzyman; Giorgio Vittorio Scagliotti; Martin C Tammemagi; Luca Bertolaccini; Natthaya Triphuridet; Rowena Yip; Alexia Rossi; Suresh Senan; Giuseppe Ferrante; Kate Brain; Carlijn van der Aalst; Lorenzo Bonomo; Dario Consonni; Jan P Van Meerbeeck; Patrick Maisonneuve; Silvia Novello; Anand Devaraj; Zaigham Saghir; Giuseppe Pelosi

doi:10.3390/cancers12061672

Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe

Giulia Veronesi, David R Baldwin, Claudia I Henschke, Simone Ghislandi, Sergio Iavicoli, Matthijs Oudkerk, Harry J De Koning, Joseph Shemesh, John K Field, Javier J Zulueta, Denis Horgan, Lucia Fiestas Navarrete, Maurizio Valentino Infante, Pierluigi Novellis, Rachael L Murray, Nir Peled, Cristiano Rampinelli, Gaetano Rocco, Witold Rzyman, Giorgio Vittorio ScagliottiMartin C Tammemagi, Luca Bertolaccini, Natthaya Triphuridet, Rowena Yip, Alexia Rossi, Suresh Senan, Giuseppe Ferrante, Kate Brain, Carlijn van der Aalst, Lorenzo Bonomo, Dario Consonni, Jan P Van Meerbeeck, Patrick Maisonneuve, Silvia Novello, Anand Devaraj, Zaigham Saghir, Giuseppe Pelosi

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Abstract

Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39-61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the "Initiative for European Lung Screening (IELS)"-a large international group of physicians and other experts concerned with lung cancer-agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached.

Original language	English
Article number	1672
Journal	Cancers
Volume	12
Issue number	6
Number of pages	24
ISSN	2072-6694
DOIs	https://doi.org/10.3390/cancers12061672
Publication status	Published - 2020

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cancers-12-01672-v2Final published version, 329 KBLicence: CC BY

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Veronesi, G., Baldwin, D. R., Henschke, C. I., Ghislandi, S., Iavicoli, S., Oudkerk, M., De Koning, H. J., Shemesh, J., Field, J. K., Zulueta, J. J., Horgan, D., Fiestas Navarrete, L., Valentino Infante, M., Novellis, P., Murray, R. L., Peled, N., Rampinelli, C., Rocco, G., Rzyman, W., ... Pelosi, G. (2020). Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe. Cancers, 12(6), Article 1672. https://doi.org/10.3390/cancers12061672

Veronesi, G, Baldwin, DR, Henschke, CI, Ghislandi, S, Iavicoli, S, Oudkerk, M, De Koning, HJ, Shemesh, J, Field, JK, Zulueta, JJ, Horgan, D, Fiestas Navarrete, L, Valentino Infante, M, Novellis, P, Murray, RL, Peled, N, Rampinelli, C, Rocco, G, Rzyman, W, Scagliotti, GV, Tammemagi, MC, Bertolaccini, L, Triphuridet, N, Yip, R, Rossi, A, Senan, S, Ferrante, G, Brain, K, van der Aalst, C, Bonomo, L, Consonni, D, Van Meerbeeck, JP, Maisonneuve, P, Novello, S, Devaraj, A, Saghir, Z & Pelosi, G 2020, 'Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe', Cancers, vol. 12, no. 6, 1672. https://doi.org/10.3390/cancers12061672

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title = "Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe",

abstract = "Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39-61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the {"}Initiative for European Lung Screening (IELS){"}-a large international group of physicians and other experts concerned with lung cancer-agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached.",

author = "Giulia Veronesi and Baldwin, {David R} and Henschke, {Claudia I} and Simone Ghislandi and Sergio Iavicoli and Matthijs Oudkerk and {De Koning}, {Harry J} and Joseph Shemesh and Field, {John K} and Zulueta, {Javier J} and Denis Horgan and {Fiestas Navarrete}, Lucia and {Valentino Infante}, Maurizio and Pierluigi Novellis and Murray, {Rachael L} and Nir Peled and Cristiano Rampinelli and Gaetano Rocco and Witold Rzyman and Scagliotti, {Giorgio Vittorio} and Tammemagi, {Martin C} and Luca Bertolaccini and Natthaya Triphuridet and Rowena Yip and Alexia Rossi and Suresh Senan and Giuseppe Ferrante and Kate Brain and {van der Aalst}, Carlijn and Lorenzo Bonomo and Dario Consonni and {Van Meerbeeck}, {Jan P} and Patrick Maisonneuve and Silvia Novello and Anand Devaraj and Zaigham Saghir and Giuseppe Pelosi",

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T1 - Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe

AU - Veronesi, Giulia

AU - Baldwin, David R

AU - Henschke, Claudia I

AU - Ghislandi, Simone

AU - Iavicoli, Sergio

AU - Oudkerk, Matthijs

AU - De Koning, Harry J

AU - Shemesh, Joseph

AU - Field, John K

AU - Zulueta, Javier J

AU - Horgan, Denis

AU - Fiestas Navarrete, Lucia

AU - Valentino Infante, Maurizio

AU - Novellis, Pierluigi

AU - Murray, Rachael L

AU - Peled, Nir

AU - Rampinelli, Cristiano

AU - Rocco, Gaetano

AU - Rzyman, Witold

AU - Scagliotti, Giorgio Vittorio

AU - Tammemagi, Martin C

AU - Bertolaccini, Luca

AU - Triphuridet, Natthaya

AU - Yip, Rowena

AU - Rossi, Alexia

AU - Senan, Suresh

AU - Ferrante, Giuseppe

AU - Brain, Kate

AU - van der Aalst, Carlijn

AU - Bonomo, Lorenzo

AU - Consonni, Dario

AU - Van Meerbeeck, Jan P

AU - Maisonneuve, Patrick

AU - Novello, Silvia

AU - Devaraj, Anand

AU - Saghir, Zaigham

AU - Pelosi, Giuseppe

PY - 2020

Y1 - 2020

N2 - Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39-61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the "Initiative for European Lung Screening (IELS)"-a large international group of physicians and other experts concerned with lung cancer-agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached.

AB - Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39-61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the "Initiative for European Lung Screening (IELS)"-a large international group of physicians and other experts concerned with lung cancer-agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached.

U2 - 10.3390/cancers12061672

DO - 10.3390/cancers12061672

M3 - Review

C2 - 32599792

SN - 2072-6694

VL - 12

JO - Cancers

JF - Cancers

IS - 6

M1 - 1672

ER -