TY - JOUR
T1 - Reduced gray matter brain volume and cortical thickness in adults with type 1 diabetes and neuropathy
AU - Hansen, Tine Maria
AU - Muthulingam, Janusiya Anajan
AU - Brock, Birgitte
AU - Drewes, Asbjørn Mohr
AU - Juhl, Anne
AU - Vorum, Henrik
AU - Jakobsen, Poul Erik
AU - Karmisholt, Jesper
AU - Brock, Christina
AU - Frøkjær, Jens Brøndum
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2022/3
Y1 - 2022/3
N2 - In this study we investigated brain morphology in adults with diabetic neuropathy. We aimed to characterize gray matter volume (GMV) and cortical thickness, and to explore associations between whole brain morphology and clinical characteristics. 46 adults with type 1 diabetes and distal symmetric peripheral neuropathy (DSPN) and 28 healthy controls underwent magnetic resonance imaging scans. GMV and cortical thickness were estimated using voxel-/surface-based morphometry. Associations between total GMV and clinical characteristics were explored. Adults with DSPN had reduced total GMV compared with controls (627.4 ± 4.1 mL vs. 642.5 ± 5.2 mL, P = 0.026). GMV loss was more pronounced for participants with painful neuropathy compared with controls (619.1±8.9 mL vs. 642.4±5.2 mL, P = 0.026) and for those with proliferative vs. non-proliferative retinopathy (609.9 ± 6.8 mL vs. 636.0 ± 4.7 mL, P = 0.003). Characteristics such as severity of neuropathy and decreased parietal N-acetylaspartate/creatine metabolite concentration seem to be related to GMV loss in this cohort. Regional GMV loss was confined to bilateral thalamus/putamen/caudate, occipital and precentral regions, and decreased cortical thickness was identified in frontal areas. Since the observed total GMV loss influenced with clinical characteristics, brain imaging could be useful for supplementary characterization of diabetic neuropathy. The regional brain changes could suggest that some areas are more vulnerable in this cohort.
AB - In this study we investigated brain morphology in adults with diabetic neuropathy. We aimed to characterize gray matter volume (GMV) and cortical thickness, and to explore associations between whole brain morphology and clinical characteristics. 46 adults with type 1 diabetes and distal symmetric peripheral neuropathy (DSPN) and 28 healthy controls underwent magnetic resonance imaging scans. GMV and cortical thickness were estimated using voxel-/surface-based morphometry. Associations between total GMV and clinical characteristics were explored. Adults with DSPN had reduced total GMV compared with controls (627.4 ± 4.1 mL vs. 642.5 ± 5.2 mL, P = 0.026). GMV loss was more pronounced for participants with painful neuropathy compared with controls (619.1±8.9 mL vs. 642.4±5.2 mL, P = 0.026) and for those with proliferative vs. non-proliferative retinopathy (609.9 ± 6.8 mL vs. 636.0 ± 4.7 mL, P = 0.003). Characteristics such as severity of neuropathy and decreased parietal N-acetylaspartate/creatine metabolite concentration seem to be related to GMV loss in this cohort. Regional GMV loss was confined to bilateral thalamus/putamen/caudate, occipital and precentral regions, and decreased cortical thickness was identified in frontal areas. Since the observed total GMV loss influenced with clinical characteristics, brain imaging could be useful for supplementary characterization of diabetic neuropathy. The regional brain changes could suggest that some areas are more vulnerable in this cohort.
KW - Brain atrophy
KW - Central nervous system
KW - Diabetes
KW - Diabetic neuropathy
KW - Magnetic resonance imaging
KW - Peripheral nervous system
UR - http://www.scopus.com/inward/record.url?scp=85117386213&partnerID=8YFLogxK
U2 - 10.1016/j.neures.2021.10.002
DO - 10.1016/j.neures.2021.10.002
M3 - Journal article
C2 - 34656646
AN - SCOPUS:85117386213
VL - 176
SP - 66
EP - 72
JO - Neuroscience research. Supplement : the official journal of the Japan Neuroscience Society
JF - Neuroscience research. Supplement : the official journal of the Japan Neuroscience Society
SN - 0921-8696
ER -