Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes

Thomas Svava Nielsen; Ulla Kampmann; Roni R Nielsen; Niels Jessen; Lotte Orskov; Steen B Pedersen; Jens Otto Lunde Jørgensen; Sten Lund; Niels Møller

doi:10.1210/jc.2012-1159

Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes

Thomas Svava Nielsen, Ulla Kampmann, Roni R Nielsen, Niels Jessen, Lotte Orskov, Steen B Pedersen, Jens Otto Lunde Jørgensen, Sten Lund, Niels Møller

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Abstract

Increased lipolysis and free fatty acid (FFA) levels contribute significantly to the pathogenesis of chronic and acute insulin resistance in type 2 diabetes, but the underlying mechanisms are uncertain.

Original language	English
Journal	The Journal of clinical endocrinology and metabolism
Volume	97
Issue number	7
Pages (from-to)	E1348-52
DOIs	https://doi.org/10.1210/jc.2012-1159
Publication status	Published - Jul 2012
Externally published	Yes

Keywords

Adipose Tissue
Blood Glucose
Carrier Proteins
Cell Cycle Proteins
Cross-Over Studies
Diabetes Mellitus, Type 2
Down-Regulation
Humans
Hypoglycemic Agents
Insulin
Insulin Infusion Systems
Lipase
Middle Aged
Phosphoproteins
RNA, Messenger
Subcutaneous Fat, Abdominal

Access to Document

10.1210/jc.2012-1159

Cite this

Nielsen, T. S., Kampmann, U., Nielsen, R. R., Jessen, N., Orskov, L., Pedersen, S. B., Jørgensen, J. O. L., Lund, S., & Møller, N. (2012). Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes. The Journal of clinical endocrinology and metabolism, 97(7), E1348-52. https://doi.org/10.1210/jc.2012-1159

Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes. / Nielsen, Thomas Svava; Kampmann, Ulla; Nielsen, Roni R; Jessen, Niels; Orskov, Lotte; Pedersen, Steen B; Jørgensen, Jens Otto Lunde; Lund, Sten; Møller, Niels.

In: The Journal of clinical endocrinology and metabolism, Vol. 97, No. 7, 07.2012, p. E1348-52.

Research output: Contribution to journal › Journal article › Research › peer-review

Nielsen, TS, Kampmann, U, Nielsen, RR, Jessen, N, Orskov, L, Pedersen, SB, Jørgensen, JOL, Lund, S & Møller, N 2012, 'Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes', The Journal of clinical endocrinology and metabolism, vol. 97, no. 7, pp. E1348-52. https://doi.org/10.1210/jc.2012-1159

Nielsen, Thomas Svava ; Kampmann, Ulla ; Nielsen, Roni R ; Jessen, Niels ; Orskov, Lotte ; Pedersen, Steen B ; Jørgensen, Jens Otto Lunde ; Lund, Sten ; Møller, Niels. / Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes. In: The Journal of clinical endocrinology and metabolism. 2012 ; Vol. 97, No. 7. pp. E1348-52.

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abstract = "Increased lipolysis and free fatty acid (FFA) levels contribute significantly to the pathogenesis of chronic and acute insulin resistance in type 2 diabetes, but the underlying mechanisms are uncertain.",

keywords = "Adipose Tissue, Blood Glucose, Carrier Proteins, Cell Cycle Proteins, Cross-Over Studies, Diabetes Mellitus, Type 2, Down-Regulation, Humans, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Lipase, Middle Aged, Phosphoproteins, RNA, Messenger, Subcutaneous Fat, Abdominal",

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KW - Humans

KW - Hypoglycemic Agents

KW - Insulin

KW - Insulin Infusion Systems

KW - Lipase

KW - Middle Aged

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