Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of patients with cystic fibrosis

Martina Ulrich; Isabelle Beer; Peter Braitmaier; Michaela Dierkes; Florian Kummer; Bernhard Krismer; Ulrike Schumacher; Ute Gräpler-Mainka; Joachim Riethmüller; Peter Østrup Jensen; Thomas Bjarnsholt; Niels Høiby; Gabriel Bellon; Gerd Döring

doi:10.1136/thx.2010.137745

Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of patients with cystic fibrosis

Martina Ulrich, Isabelle Beer, Peter Braitmaier, Michaela Dierkes, Florian Kummer, Bernhard Krismer, Ulrike Schumacher, Ute Gräpler-Mainka, Joachim Riethmüller, Peter Østrup Jensen, Thomas Bjarnsholt, Niels Høiby, Gabriel Bellon, Gerd Döring

Research output: Contribution to journal › Journal article › Research › peer-review

77 Citations (Scopus)

Abstract

Patients with cystic fibrosis (CF) with Pseudomonas aeruginosa lung infections produce endobronchial mucus plugs allowing growth of obligate anaerobes including Prevotella spp. Whether obligate anaerobes contribute to the pathophysiology of CF lung disease is unknown.

Original language	English
Journal	Thorax
Volume	65
Issue number	11
Pages (from-to)	978-984
Number of pages	7
ISSN	0040-6376
DOIs	https://doi.org/10.1136/thx.2010.137745
Publication status	Published - 1 Nov 2010

Keywords

Animals
Antibodies, Bacterial
Bacteroidaceae Infections
Bronchoalveolar Lavage Fluid
Cells, Cultured
Colony Count, Microbial
Cystic Fibrosis
Humans
Lung
Mice
Mice, Inbred C57BL
Opportunistic Infections
Prevotella intermedia
Pseudomonas Infections
Pseudomonas aeruginosa
Respiratory Tract Infections
Sputum
Virulence

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10.1136/thx.2010.137745

Cite this

Ulrich, M., Beer, I., Braitmaier, P., Dierkes, M., Kummer, F., Krismer, B., Schumacher, U., Gräpler-Mainka, U., Riethmüller, J., Jensen, P. Ø., Bjarnsholt, T., Høiby, N., Bellon, G., & Döring, G. (2010). Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of patients with cystic fibrosis. Thorax, 65(11), 978-984. https://doi.org/10.1136/thx.2010.137745

Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of patients with cystic fibrosis. / Ulrich, Martina; Beer, Isabelle; Braitmaier, Peter; Dierkes, Michaela; Kummer, Florian; Krismer, Bernhard; Schumacher, Ulrike; Gräpler-Mainka, Ute; Riethmüller, Joachim; Jensen, Peter Østrup ; Bjarnsholt, Thomas ; Høiby, Niels; Bellon, Gabriel; Döring, Gerd.

In: Thorax, Vol. 65, No. 11, 01.11.2010, p. 978-984.

Research output: Contribution to journal › Journal article › Research › peer-review

Ulrich, M, Beer, I, Braitmaier, P, Dierkes, M, Kummer, F, Krismer, B, Schumacher, U, Gräpler-Mainka, U, Riethmüller, J, Jensen, PØ , Bjarnsholt, T , Høiby, N, Bellon, G & Döring, G 2010, 'Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of patients with cystic fibrosis', Thorax, vol. 65, no. 11, pp. 978-984. https://doi.org/10.1136/thx.2010.137745

Ulrich, Martina ; Beer, Isabelle ; Braitmaier, Peter ; Dierkes, Michaela ; Kummer, Florian ; Krismer, Bernhard ; Schumacher, Ulrike ; Gräpler-Mainka, Ute ; Riethmüller, Joachim ; Jensen, Peter Østrup ; Bjarnsholt, Thomas ; Høiby, Niels ; Bellon, Gabriel ; Döring, Gerd. / Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of patients with cystic fibrosis. In: Thorax. 2010 ; Vol. 65, No. 11. pp. 978-984.

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