Abstract
Poly(ethylcyanoacrylate) (PECA) nanoparticles containing the chemical sterilitant D-Lys6-GnRH were prepared by an in situ interfacial polymerization technique. Their potential as a peroral delivery system for biocontrol of the brushtail possum, a major pest species in New Zealand, was evaluated. Peptide release from resulting particles was studied in vitro in artificial gastric juice (AGJ), simulated intestinal fluids (SIF) and brushtail possum plasma. The nanoparticles released a small fraction of bioactive over 6h in AGJ and SIF (
Original language | English |
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Journal | Journal of controlled release : official journal of the Controlled Release Society |
Volume | 149 |
Issue number | 3 |
Pages (from-to) | 307-13 |
Number of pages | 7 |
DOIs | |
Publication status | Published - 2011 |
Externally published | Yes |