Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control

Alexandra P Kafka; Bernie J McLeod; Thomas Rades; Arlene McDowell

doi:10.1016/j.jconrel.2010.10.029

Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control

Alexandra P Kafka, Bernie J McLeod, Thomas Rades, Arlene McDowell

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

Abstract

Poly(ethylcyanoacrylate) (PECA) nanoparticles containing the chemical sterilitant D-Lys6-GnRH were prepared by an in situ interfacial polymerization technique. Their potential as a peroral delivery system for biocontrol of the brushtail possum, a major pest species in New Zealand, was evaluated. Peptide release from resulting particles was studied in vitro in artificial gastric juice (AGJ), simulated intestinal fluids (SIF) and brushtail possum plasma. The nanoparticles released a small fraction of bioactive over 6h in AGJ and SIF (

Original language	English
Journal	Journal of controlled release : official journal of the Controlled Release Society
Volume	149
Issue number	3
Pages (from-to)	307-13
Number of pages	7
DOIs	https://doi.org/10.1016/j.jconrel.2010.10.029
Publication status	Published - 2011
Externally published	Yes

Access to Document

10.1016/j.jconrel.2010.10.029

Cite this

Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control. / Kafka, Alexandra P; McLeod, Bernie J; Rades, Thomas; McDowell, Arlene.

In: Journal of controlled release : official journal of the Controlled Release Society, Vol. 149, No. 3, 2011, p. 307-13.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - McDowell, Arlene

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