TY - JOUR
T1 - Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis
T2 - A MASK-air study
AU - Sousa-Pinto, Bernardo
AU - Louis, Gilles
AU - Vieira, Rafael J.
AU - Czarlewski, Wienczyslawa
AU - Anto, Josep M.
AU - Amaral, Rita
AU - Sá-Sousa, Ana
AU - Brussino, Luisa
AU - Canonica, G. Walter
AU - Loureiro, Claudia Chaves
AU - Cruz, Alvaro A.
AU - Gemicioglu, Bilun
AU - Haahtela, Tari
AU - Kupczyk, Maciej
AU - Kvedariene, Violeta
AU - Larenas-Linnemann, Desirée E.
AU - Pham-Thi, Nhân
AU - Puggioni, Francesca
AU - Regateiro, Frederico S.
AU - Romantowski, Jan
AU - Sastre, Joaquin
AU - Scichilone, Nicola
AU - Taborda-Barata, Luis
AU - Ventura, Maria Teresa
AU - Agache, Ioana
AU - Bedbrook, Anna
AU - Benfante, Alida
AU - Bergmann, Karl C.
AU - Bosnic-Anticevich, Sinthia
AU - Bonini, Matteo
AU - Boulet, Louis Philippe
AU - Brusselle, Guy
AU - Buhl, Roland
AU - Cecchi, Lorenzo
AU - Charpin, Denis
AU - Costa, Elisio M.
AU - Del Giacco, Stefano
AU - Jutel, Marek
AU - Klimek, Ludger
AU - Kuna, Piotr
AU - Laune, Daniel
AU - Makela, Mika
AU - Morais-Almeida, Mario
AU - Nadif, Rachel
AU - Niedoszytko, Marek
AU - Papadopoulos, Nikolaos G.
AU - Papi, Alberto
AU - Pfaar, Oliver
AU - Rivero-Yeverino, Daniela
AU - Ulrik, Charlotte Suppli
AU - MASK-air think tank
N1 - Publisher Copyright:
© 2024 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.
PY - 2024
Y1 - 2024
N2 - Rationale: It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives: To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods: In this cross-sectional study, we assessed real-world data using the MASK-air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma. Measurement and Main Results: We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma. Conclusions: Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.
AB - Rationale: It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives: To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods: In this cross-sectional study, we assessed real-world data using the MASK-air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma. Measurement and Main Results: We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma. Conclusions: Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.
KW - asthma
KW - diagnosis
KW - dyspnea
KW - mHealth
KW - wheezing
U2 - 10.1002/clt2.12358
DO - 10.1002/clt2.12358
M3 - Journal article
C2 - 38804596
AN - SCOPUS:85195109029
SN - 2045-7022
VL - 14
JO - Clinical and Translational Allergy
JF - Clinical and Translational Allergy
IS - 6
M1 - e12358
ER -