Reply to Rumrich and colleagues (What does “Parkinson’s disease mortality” mean?)

Thomas Cole-Hunter; Jiawei Zhang; Youn-Hee Lim; Evangelia Samoli; Jie Chen; Maciej Strak; Kathrin Wolf; Gudrun Weinmayr; Emanuel Zitt; Barbara Hoffmann; Karl-Heinz Jöckel; Laust H Mortensen; Matthias Ketzel; Diego Yacamán Méndez; Petter Ljungman; Gabriele Nagel; Göran Pershagen; Debora Rizzuto; Sara Schramm; Bert Brunekreef; Gerard Hoek; Zorana J Andersen

doi:10.1016/j.envint.2023.107853

Reply to Rumrich and colleagues (What does “Parkinson’s disease mortality” mean?)

Thomas Cole-Hunter, Jiawei Zhang, Youn-Hee Lim, Evangelia Samoli, Jie Chen, Maciej Strak, Kathrin Wolf, Gudrun Weinmayr, Emanuel Zitt, Barbara Hoffmann, Karl-Heinz Jöckel, Laust H Mortensen, Matthias Ketzel, Diego Yacamán Méndez, Petter Ljungman, Gabriele Nagel, Göran Pershagen, Debora Rizzuto, Sara Schramm, Bert BrunekreefGerard Hoek, Zorana J Andersen

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Abstract

We thank Rumrich and colleagues for their interest and correspondence concerning our recently published article investigating the effects of long-term air pollution exposure on Parkinson’s disease (PD) mortality in a large pooled European (ELAPSE project) cohort (Cole-Hunter, 2023). In response, we agree that in general a more careful discussion of results is warranted due to the fact that air pollution as a specific risk factor is under-studied within the context of neurodegenerative diseases; hence, studies such as ours need to be performed albeit with some inherent limitations. Prior to our study, only two studies had examined long-term exposure to air pollution with respect to PD mortality, with one detecting significant positive associations for O3 (Zhao, 2021), and another finding a suggestive positive association for PM2.5 (Rhew et al., 2021). Most studies have examined PD incidence with mixed results (see Supplemental Table S1 of our original article (Cole-Hunter, 2023).

Original language	English
Article number	107853
Journal	Environment International
Volume	173
Number of pages	2
ISSN	0160-4120
DOIs	https://doi.org/10.1016/j.envint.2023.107853
Publication status	Published - 2023

Keywords

Humans
Parkinson Disease

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Cole-Hunter, T., Zhang, J., Lim, Y.-H., Samoli, E., Chen, J., Strak, M., Wolf, K., Weinmayr, G., Zitt, E., Hoffmann, B., Jöckel, K.-H., Mortensen, L. H., Ketzel, M., Méndez, D. Y., Ljungman, P., Nagel, G., Pershagen, G., Rizzuto, D., Schramm, S., ... Andersen, Z. J. (2023). Reply to Rumrich and colleagues (What does “Parkinson’s disease mortality” mean?). Environment International, 173, Article 107853. https://doi.org/10.1016/j.envint.2023.107853

Cole-Hunter, T , Zhang, J , Lim, Y-H, Samoli, E, Chen, J, Strak, M, Wolf, K, Weinmayr, G, Zitt, E, Hoffmann, B, Jöckel, K-H, Mortensen, LH, Ketzel, M, Méndez, DY, Ljungman, P, Nagel, G, Pershagen, G, Rizzuto, D, Schramm, S, Brunekreef, B, Hoek, G & Andersen, ZJ 2023, 'Reply to Rumrich and colleagues (What does “Parkinson’s disease mortality” mean?)', Environment International, vol. 173, 107853. https://doi.org/10.1016/j.envint.2023.107853

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title = "Reply to Rumrich and colleagues (What does “Parkinson{\textquoteright}s disease mortality” mean?)",

abstract = "We thank Rumrich and colleagues for their interest and correspondence concerning our recently published article investigating the effects of long-term air pollution exposure on Parkinson{\textquoteright}s disease (PD) mortality in a large pooled European (ELAPSE project) cohort (Cole-Hunter, 2023). In response, we agree that in general a more careful discussion of results is warranted due to the fact that air pollution as a specific risk factor is under-studied within the context of neurodegenerative diseases; hence, studies such as ours need to be performed albeit with some inherent limitations. Prior to our study, only two studies had examined long-term exposure to air pollution with respect to PD mortality, with one detecting significant positive associations for O3 (Zhao, 2021), and another finding a suggestive positive association for PM2.5 (Rhew et al., 2021). Most studies have examined PD incidence with mixed results (see Supplemental Table S1 of our original article (Cole-Hunter, 2023).",

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author = "Thomas Cole-Hunter and Jiawei Zhang and Youn-Hee Lim and Evangelia Samoli and Jie Chen and Maciej Strak and Kathrin Wolf and Gudrun Weinmayr and Emanuel Zitt and Barbara Hoffmann and Karl-Heinz J{\"o}ckel and Mortensen, {Laust H} and Matthias Ketzel and M{\'e}ndez, {Diego Yacam{\'a}n} and Petter Ljungman and Gabriele Nagel and G{\"o}ran Pershagen and Debora Rizzuto and Sara Schramm and Bert Brunekreef and Gerard Hoek and Andersen, {Zorana J}",

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AU - Cole-Hunter, Thomas

AU - Zhang, Jiawei

AU - Lim, Youn-Hee

AU - Samoli, Evangelia

AU - Chen, Jie

AU - Strak, Maciej

AU - Wolf, Kathrin

AU - Weinmayr, Gudrun

AU - Zitt, Emanuel

AU - Hoffmann, Barbara

AU - Jöckel, Karl-Heinz

AU - Mortensen, Laust H

AU - Ketzel, Matthias

AU - Méndez, Diego Yacamán

AU - Ljungman, Petter

AU - Nagel, Gabriele

AU - Pershagen, Göran

AU - Rizzuto, Debora

AU - Schramm, Sara

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Andersen, Zorana J

PY - 2023

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AB - We thank Rumrich and colleagues for their interest and correspondence concerning our recently published article investigating the effects of long-term air pollution exposure on Parkinson’s disease (PD) mortality in a large pooled European (ELAPSE project) cohort (Cole-Hunter, 2023). In response, we agree that in general a more careful discussion of results is warranted due to the fact that air pollution as a specific risk factor is under-studied within the context of neurodegenerative diseases; hence, studies such as ours need to be performed albeit with some inherent limitations. Prior to our study, only two studies had examined long-term exposure to air pollution with respect to PD mortality, with one detecting significant positive associations for O3 (Zhao, 2021), and another finding a suggestive positive association for PM2.5 (Rhew et al., 2021). Most studies have examined PD incidence with mixed results (see Supplemental Table S1 of our original article (Cole-Hunter, 2023).

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KW - Parkinson Disease

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DO - 10.1016/j.envint.2023.107853

M3 - Comment/debate

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SN - 0160-4120

VL - 173

JO - Environment International

JF - Environment International

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