Resistance exercise-induced hypertrophy: A potential role for rapamycin-insensitive mTOR

Riki Ogasawara*, Thomas Elbenhardt Jensen, Craig A Goodman, Troy A Hornberger

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

36 Citations (Scopus)

Abstract

The mechanistic target of rapamycin (mTOR) exerts both rapamycin-sensitive and rapamycin-insensitive signaling events, and the rapamycin-sensitive components of mTOR signaling have been widely implicated in the pathway through which resistance exercise induces skeletal muscle hypertrophy. This review explores the hypothesis that rapamycin-insensitive components of mTOR signaling also contribute to this highly important process.

Summary: This review examines whether both rapamycin-sensitive, and rapamycin-insensitive, components of mTOR signaling contribute to the hypertrophic effects of resistance exercise.

Original languageEnglish
JournalExercise and Sport Sciences Reviews
Volume47
Issue number3
Pages (from-to)188-194
ISSN0091-6331
DOIs
Publication statusPublished - 2019

Keywords

  • Faculty of Science
  • Exercise
  • Hypertrophy
  • Protein synthesis
  • mTOR
  • mTORC1
  • mTORC2
  • Rapamycin

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