Resolution of the three dimensional structure of components of the glomerular filtration barrier

Kenton P Arkill; Klaus Qvortrup; Tobias Starborg; Judith M Mantell; Carlo Knupp; Charles C Michel; Steve J Harper; Andy Hj Salmon; John M Squire; Dave O Bates; Chris R Neal

doi:10.1186/1471-2369-15-24

Resolution of the three dimensional structure of components of the glomerular filtration barrier

Kenton P Arkill, Klaus Qvortrup, Tobias Starborg, Judith M Mantell, Carlo Knupp, Charles C Michel, Steve J Harper, Andy Hj Salmon, John M Squire, Dave O Bates, Chris R Neal

Core Facility for Integrated Microscopy

Research output: Contribution to journal › Journal article › Research › peer-review

58 Citations (Scopus)

Abstract

The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane and the podocyte foot processes. However, recent studies have suggested that at least two additional layers contribute to the function of the GFB, the endothelial glycocalyx on the vascular side, and the sub-podocyte space on the urinary side. To investigate the structure of these additional layers is difficult as it requires three-dimensional reconstruction of delicate sub-microscopic (

Original language	English
Article number	24
Journal	B M C Nephrology
Volume	15
Issue number	1
Pages (from-to)	1-13
Number of pages	13
ISSN	1471-2369
DOIs	https://doi.org/10.1186/1471-2369-15-24
Publication status	Published - 1 Feb 2014

Access to Document

10.1186/1471-2369-15-24

Cite this

Resolution of the three dimensional structure of components of the glomerular filtration barrier. / Arkill, Kenton P; Qvortrup, Klaus; Starborg, Tobias; Mantell, Judith M; Knupp, Carlo; Michel, Charles C; Harper, Steve J; Salmon, Andy Hj; Squire, John M; Bates, Dave O; Neal, Chris R.

In: B M C Nephrology, Vol. 15, No. 1, 24, 01.02.2014, p. 1-13.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Starborg, Tobias

AU - Mantell, Judith M

AU - Knupp, Carlo

AU - Michel, Charles C

AU - Harper, Steve J

AU - Salmon, Andy Hj

AU - Squire, John M

AU - Bates, Dave O

AU - Neal, Chris R

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