Abstract
The majority of small molecule compounds targeting chemokine receptors share a similar pharmacophore with a centrally located aliphatic positive charge and flanking aromatic moieties. Here we describe a novel piperidine-based compound with structural similarity to previously described CCR8-specific agonists, but containing a unique phenyl-tetrazol moiety which, in addition to activity at CCR8 was also active at CCR1.
Original language | English |
---|---|
Journal | British Journal of Pharmacology |
Volume | 166 |
Issue number | 1 |
Pages (from-to) | 258-75 |
Number of pages | 18 |
ISSN | 0007-1188 |
DOIs | |
Publication status | Published - May 2012 |
Keywords
- Animals
- Binding Sites
- COS Cells
- Cercopithecus aethiops
- Glutamic Acid
- Humans
- Inositol 1,4,5-Trisphosphate
- Ligands
- Models, Molecular
- Piperidines
- Point Mutation
- Receptors, CCR1
- Receptors, CCR8
- Tetrazoles