Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery

Tracey McLaughlin; Marcia Peck; Jens Holst; Carolyn Deacon

doi:10.1210/jc.2009-1628

Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery

Tracey McLaughlin, Marcia Peck, Jens Holst, Carolyn Deacon

Endocrinology and Metabolism

Research output: Contribution to journal › Journal article › Research › peer-review

148 Citations (Scopus)

Abstract

Severe hypoglycemia after Roux-en-Y gastric bypass surgery (RYGB) is an increasingly recognized condition, characterized by neuroglycopenia and inappropriately elevated insulin concentrations that occur primarily in the postprandial state. Both pathophysiology and treatment of this disorder remain elusive, but it has been postulated that hyperplasia and/or hypertrophy of beta-cells due to morbid obesity and/or postsurgical nesidioblastosis may contribute.

Original language	English
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	95
Issue number	4
Pages (from-to)	1851-5
Number of pages	5
ISSN	0021-972X
DOIs	https://doi.org/10.1210/jc.2009-1628
Publication status	Published - Apr 2010

Keywords

Adult
Blood Glucose
Body Mass Index
Female
Gastric Bypass
Gastric Inhibitory Polypeptide
Glucagon
Glucagon-Like Peptide 1
Humans
Hyperinsulinism
Hypoglycemia
Insulin
Nutritional Status
Obesity, Morbid
Postoperative Complications

Access to Document

10.1210/jc.2009-1628

Cite this

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title = "Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery",

abstract = "Severe hypoglycemia after Roux-en-Y gastric bypass surgery (RYGB) is an increasingly recognized condition, characterized by neuroglycopenia and inappropriately elevated insulin concentrations that occur primarily in the postprandial state. Both pathophysiology and treatment of this disorder remain elusive, but it has been postulated that hyperplasia and/or hypertrophy of beta-cells due to morbid obesity and/or postsurgical nesidioblastosis may contribute.",

keywords = "Adult, Blood Glucose, Body Mass Index, Female, Gastric Bypass, Gastric Inhibitory Polypeptide, Glucagon, Glucagon-Like Peptide 1, Humans, Hyperinsulinism, Hypoglycemia, Insulin, Nutritional Status, Obesity, Morbid, Postoperative Complications",

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T1 - Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery

AU - McLaughlin, Tracey

AU - Peck, Marcia

AU - Holst, Jens

AU - Deacon, Carolyn

PY - 2010/4

Y1 - 2010/4

N2 - Severe hypoglycemia after Roux-en-Y gastric bypass surgery (RYGB) is an increasingly recognized condition, characterized by neuroglycopenia and inappropriately elevated insulin concentrations that occur primarily in the postprandial state. Both pathophysiology and treatment of this disorder remain elusive, but it has been postulated that hyperplasia and/or hypertrophy of beta-cells due to morbid obesity and/or postsurgical nesidioblastosis may contribute.

AB - Severe hypoglycemia after Roux-en-Y gastric bypass surgery (RYGB) is an increasingly recognized condition, characterized by neuroglycopenia and inappropriately elevated insulin concentrations that occur primarily in the postprandial state. Both pathophysiology and treatment of this disorder remain elusive, but it has been postulated that hyperplasia and/or hypertrophy of beta-cells due to morbid obesity and/or postsurgical nesidioblastosis may contribute.

KW - Adult

KW - Blood Glucose

KW - Body Mass Index

KW - Female

KW - Gastric Bypass

KW - Gastric Inhibitory Polypeptide

KW - Glucagon

KW - Glucagon-Like Peptide 1

KW - Humans

KW - Hyperinsulinism

KW - Hypoglycemia

KW - Insulin

KW - Nutritional Status

KW - Obesity, Morbid

KW - Postoperative Complications

U2 - 10.1210/jc.2009-1628

DO - 10.1210/jc.2009-1628

M3 - Journal article

C2 - 20133462

VL - 95

SP - 1851

EP - 1855

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 4

ER -