Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia

Tadeusz Robak, Anna Dmoszynska, Philippe Solal-Céligny, Krzysztof Warzocha, Javier Loscertales, John Catalano, Boris V Afanasiev, Loree Larratt, Christian H Geisler, Marco Montillo, Ilya Zyuzgin, Peter S Ganly, Caroline Dartigeas, András Rosta, Jörg Maurer, Myriam Mendila, M Wayne Saville, Nancy Valente, Michael K Wenger, Sergey I Moiseev

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Abstract

Rituximab, a monoclonal antibody that targets the CD20 cell surface antigen, has clinical activity in patients with non-Hodgkin's lymphoma and other B-lymphocyte disorders when administered alone or in combination with chemotherapy. Promising results have previously been reported in nonrandomized studies in patients with chronic lymphocytic leukemia (CLL). This trial was designed to compare chemoimmunotherapy with chemotherapy alone in patients with previously treated CLL.
Original languageEnglish
JournalJournal of Clinical Oncology
Volume28
Issue number10
Pages (from-to)1756-65
Number of pages10
ISSN0732-183X
DOIs
Publication statusPublished - 1 Apr 2010

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