Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA)

Neil R Poulter; Hans Wedel; Björn Dahlöf; Peter S Sever; D Gareth Beevers; Mark Caulfield; Sverre E Kjeldsen; Arni Kristinsson; Gordon T McInnes; Jesper Mehlsen; Markku Nieminen; Eoin O'Brien; Jan Ostergren; Stuart Pocock; ASCOT Investigators

doi:http://dx.doi.org/10.1016/S0140-6736(05)67186-3

Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA)

Neil R Poulter, Hans Wedel, Björn Dahlöf, Peter S Sever, D Gareth Beevers, Mark Caulfield, Sverre E Kjeldsen, Arni Kristinsson, Gordon T McInnes, Jesper Mehlsen, Markku Nieminen, Eoin O'Brien, Jan Ostergren, Stuart Pocock, ASCOT Investigators

Department of Clinical Medicine

Research output: Contribution to journal › Journal article › Research › peer-review

325 Citations (Scopus)

Abstract

Results of the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA) show significantly lower rates of coronary and stroke events in individuals allocated an amlodipine-based combination drug regimen than in those allocated an atenolol-based combination drug regimen (HR 0.86 and 0.77, respectively). Our aim was to assess to what extent these differences were due to significant differences in blood pressures and in other variables noted after randomisation.

Original language	English
Journal	Lancet
Volume	366
Issue number	9489
Pages (from-to)	907-13
Number of pages	7
ISSN	0140-6736
DOIs	https://doi.org/10.1016/S0140-6736(05)67186-3
Publication status	Published - Sep 2005

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http://dx.doi.org/10.1016/S0140-6736(05)67186-3

Cite this

Poulter, N. R., Wedel, H., Dahlöf, B., Sever, P. S., Beevers, D. G., Caulfield, M., Kjeldsen, S. E., Kristinsson, A., McInnes, G. T., Mehlsen, J., Nieminen, M., O'Brien, E., Ostergren, J., Pocock, S., & ASCOT Investigators (2005). Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA). Lancet, 366(9489), 907-13. https://doi.org/10.1016/S0140-6736(05)67186-3

Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA). / Poulter, Neil R; Wedel, Hans; Dahlöf, Björn; Sever, Peter S; Beevers, D Gareth; Caulfield, Mark; Kjeldsen, Sverre E; Kristinsson, Arni; McInnes, Gordon T; Mehlsen, Jesper; Nieminen, Markku; O'Brien, Eoin; Ostergren, Jan; Pocock, Stuart; ASCOT Investigators.

In: Lancet, Vol. 366, No. 9489, 09.2005, p. 907-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Poulter, NR, Wedel, H, Dahlöf, B, Sever, PS, Beevers, DG, Caulfield, M, Kjeldsen, SE, Kristinsson, A, McInnes, GT, Mehlsen, J, Nieminen, M, O'Brien, E, Ostergren, J, Pocock, S & ASCOT Investigators 2005, 'Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA)', Lancet, vol. 366, no. 9489, pp. 907-13. https://doi.org/10.1016/S0140-6736(05)67186-3

Poulter, Neil R ; Wedel, Hans ; Dahlöf, Björn ; Sever, Peter S ; Beevers, D Gareth ; Caulfield, Mark ; Kjeldsen, Sverre E ; Kristinsson, Arni ; McInnes, Gordon T ; Mehlsen, Jesper ; Nieminen, Markku ; O'Brien, Eoin ; Ostergren, Jan ; Pocock, Stuart ; ASCOT Investigators. / Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA). In: Lancet. 2005 ; Vol. 366, No. 9489. pp. 907-13.

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abstract = "Results of the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA) show significantly lower rates of coronary and stroke events in individuals allocated an amlodipine-based combination drug regimen than in those allocated an atenolol-based combination drug regimen (HR 0.86 and 0.77, respectively). Our aim was to assess to what extent these differences were due to significant differences in blood pressures and in other variables noted after randomisation.",

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AU - Sever, Peter S

AU - Beevers, D Gareth

AU - Caulfield, Mark

AU - Kjeldsen, Sverre E

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AU - McInnes, Gordon T

AU - Mehlsen, Jesper

AU - Nieminen, Markku

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AU - Pocock, Stuart

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AB - Results of the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA) show significantly lower rates of coronary and stroke events in individuals allocated an amlodipine-based combination drug regimen than in those allocated an atenolol-based combination drug regimen (HR 0.86 and 0.77, respectively). Our aim was to assess to what extent these differences were due to significant differences in blood pressures and in other variables noted after randomisation.

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