Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?

Clare L Hawkins

doi:10.1038/ki.2014.256

Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?

Clare L Hawkins

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Abstract

Cyanate is a uremic toxin responsible for the carbamylation of proteins, which has been implicated as playing a key role in accelerating the progression of atherosclerosis in patients with chronic kidney disease. El-Gamal et al. report that while cyanate promotes protein carbamylation in vivo, the resulting endothelial dysfunction observed is consistent with reactions mediated by cyanate itself, rather than by carbamylated proteins. This provides new insight into the relationship between uremia and cardiovascular disease.

Original language	English
Journal	Kidney International
Volume	86
Issue number	5
Pages (from-to)	875-7
Number of pages	3
ISSN	0085-2538
DOIs	https://doi.org/10.1038/ki.2014.256
Publication status	Published - Nov 2014
Externally published	Yes

Keywords

Animals
Aorta
Cyanates
Endothelial Cells
Endothelium, Vascular
Humans
Male
Vasodilation
Comment
Journal Article
Research Support, Non-U.S. Gov't

Access to Document

10.1038/ki.2014.256

Cite this

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title = "Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?",

abstract = "Cyanate is a uremic toxin responsible for the carbamylation of proteins, which has been implicated as playing a key role in accelerating the progression of atherosclerosis in patients with chronic kidney disease. El-Gamal et al. report that while cyanate promotes protein carbamylation in vivo, the resulting endothelial dysfunction observed is consistent with reactions mediated by cyanate itself, rather than by carbamylated proteins. This provides new insight into the relationship between uremia and cardiovascular disease.",

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AB - Cyanate is a uremic toxin responsible for the carbamylation of proteins, which has been implicated as playing a key role in accelerating the progression of atherosclerosis in patients with chronic kidney disease. El-Gamal et al. report that while cyanate promotes protein carbamylation in vivo, the resulting endothelial dysfunction observed is consistent with reactions mediated by cyanate itself, rather than by carbamylated proteins. This provides new insight into the relationship between uremia and cardiovascular disease.

KW - Animals

KW - Aorta

KW - Cyanates

KW - Endothelial Cells

KW - Endothelium, Vascular

KW - Humans

KW - Male

KW - Vasodilation

KW - Comment

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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DO - 10.1038/ki.2014.256

M3 - Journal article

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JO - Kidney International

JF - Kidney International

SN - 0085-2538

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