RT-PCR versus immunohistochemistry for correlation and quantification of ERCC1, BRCA1, TUBB3 and RRM1 in NSCLC

Adam Christian Vilmar, J Garcia-Foncillas, M Huarriz, E Santoni-Rugiu, J B Sorensen, Adam Christian Vilmar

Research output: Contribution to journalJournal articleResearchpeer-review

43 Citations (Scopus)

Abstract

Customized chemotherapy is increasingly used in the management of patients with advanced non-small cell lung cancer (NSCLC). However, the most reliable methodology to determine biomarker status is neither fully elucidated nor agreed upon. Accordingly, we evaluated the predictive efficiency of qRT-PCR and immunohistochemical analysis (IHC) on excision cross complementation group 1 (ERCC1), breast cancer susceptibility gene 1 (BRCA1), ribonucleotide reductase subunit M1 (RRM1) and class III ß-tubulin (TUBB3).
Original languageEnglish
JournalLung Cancer
Volume75
Issue number3
Pages (from-to)306-12
Number of pages7
ISSN0169-5002
DOIs
Publication statusPublished - 2012

Cite this