TY - JOUR
T1 - RUBIC (ReproUnion Biobank and Infertility Cohort)
T2 - A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity
AU - Priskorn, Lærke
AU - Tøttenborg, Sandra Søgaard
AU - Almstrup, Kristian
AU - Andersson, Anna Maria
AU - Axelsson, Jonatan
AU - Bräuner, Elvira Vaclavik
AU - Elenkov, Angel
AU - Freiesleben, Nina la Cour
AU - Giwercman, Yvonne Lundberg
AU - Grøndahl, Marie Louise
AU - Hansen, Ann Holm
AU - Hansen, Laura Smidt
AU - Henic, Emir
AU - Kitlinski, Margareta Laczna
AU - Landersoe, Selma Kloeve
AU - Lindh, Christian
AU - Løkkegaard, Ellen Leth
AU - Malm, Johan
AU - Olsen, Kristina Wendelboe
AU - Petersen, Kajsa Uglevig
AU - Schmidt, Lone
AU - Stormlund, Sacha
AU - Svendsen, Pernille Fog
AU - Vassard, Ditte
AU - Wang, Nathalie Friis
AU - Zedeler, Anne
AU - Bhasin, Shalender
AU - Chavarro, Jorge
AU - Eisenberg, Michael L.
AU - Hauser, Russ
AU - Huhtaniemi, Ilpo
AU - Krawetz, Stephen A.
AU - Marko-Varga, György
AU - Salonia, Andrea
AU - Toppari, Jorma
AU - Juul, Anders
AU - Jørgensen, Niels
AU - Nielsen, Henriette Svarre
AU - Pinborg, Anja
AU - Rylander, Lars
AU - Giwercman, Aleksander
N1 - Publisher Copyright:
© 2021 American Society of Andrology and European Academy of Andrology
PY - 2021
Y1 - 2021
N2 - Background: Infertility affects 15%–25% of all couples during their reproductive life span. It is a significant societal and public health problem with potential psychological, social, and economic consequences. Furthermore, infertility has been linked to adverse long-term health outcomes. Despite the advanced diagnostic and therapeutic techniques available, approximately 30% of infertile couples do not obtain a live birth after fertility treatment. For these couples, there are no further options to increase their chances of a successful pregnancy and live birth. Objectives: Three overall questions will be studied: (1) What are the risk factors and natural life courses of infertility, early embryonic loss, and adverse pregnancy outcomes? (2) Can we develop new diagnostic and prognostic biomarkers for fecundity and treatment success? And (3) what are the health characteristics of women and men in infertile couples at the time of fertility treatment and during long-term follow-up?. Material and Methods: ReproUnion Biobank and Infertility Cohort (RUBIC) is established as an add-on to the routine fertility management at Copenhagen University Hospital Departments in the Capital Region of Denmark and Reproductive Medicine Centre at Skåne University Hospital in Sweden. The aim is to include a total of 5000 couples equally distributed between Denmark and Sweden. The first patients were enrolled in June 2020. All eligible infertile couples are prospectively asked to participate in the project. Participants complete an extensive questionnaire and undergo a physical examination and collection of biospecimens (blood, urine, hair, saliva, rectal swabs, feces, semen, endometrial biopsies, and vaginal swabs). After the cohort is established, the couples will be linked to the Danish and Swedish national registers to obtain information on parental, perinatal, childhood, and adult life histories, including disease and medication history. This will enable us to understand the causes of infertility and identify novel therapeutic options for this important societal problem.
AB - Background: Infertility affects 15%–25% of all couples during their reproductive life span. It is a significant societal and public health problem with potential psychological, social, and economic consequences. Furthermore, infertility has been linked to adverse long-term health outcomes. Despite the advanced diagnostic and therapeutic techniques available, approximately 30% of infertile couples do not obtain a live birth after fertility treatment. For these couples, there are no further options to increase their chances of a successful pregnancy and live birth. Objectives: Three overall questions will be studied: (1) What are the risk factors and natural life courses of infertility, early embryonic loss, and adverse pregnancy outcomes? (2) Can we develop new diagnostic and prognostic biomarkers for fecundity and treatment success? And (3) what are the health characteristics of women and men in infertile couples at the time of fertility treatment and during long-term follow-up?. Material and Methods: ReproUnion Biobank and Infertility Cohort (RUBIC) is established as an add-on to the routine fertility management at Copenhagen University Hospital Departments in the Capital Region of Denmark and Reproductive Medicine Centre at Skåne University Hospital in Sweden. The aim is to include a total of 5000 couples equally distributed between Denmark and Sweden. The first patients were enrolled in June 2020. All eligible infertile couples are prospectively asked to participate in the project. Participants complete an extensive questionnaire and undergo a physical examination and collection of biospecimens (blood, urine, hair, saliva, rectal swabs, feces, semen, endometrial biopsies, and vaginal swabs). After the cohort is established, the couples will be linked to the Danish and Swedish national registers to obtain information on parental, perinatal, childhood, and adult life histories, including disease and medication history. This will enable us to understand the causes of infertility and identify novel therapeutic options for this important societal problem.
KW - epigenetics
KW - human microbiome/microbiota
KW - infertility
KW - medically assisted reproduction
KW - reproductive disorders
KW - semen quality
U2 - 10.1111/andr.13063
DO - 10.1111/andr.13063
M3 - Journal article
C2 - 34114375
AN - SCOPUS:85108217849
VL - 9
SP - 1828
EP - 1842
JO - Journal of Andrology
JF - Journal of Andrology
SN - 2047-2919
IS - 6
ER -