TY - JOUR
T1 - School performance and psychiatric comorbidity in childhood absence epilepsy
T2 - A Danish cohort study
AU - Boesen, Magnus Spangsberg
AU - Børresen, Malene Landbo
AU - Christensen, Søren Kirchhoff
AU - Klein-Petersen, Amalie Wandel
AU - El Mahdaoui, Sahla
AU - Sagar, Malini Vendela
AU - Schou, Emilie
AU - Eltvedt, Anna Korsgaard
AU - Cacic Hribljan, Melita
AU - Born, Alfred Peter
AU - Uldall, Peter Vilhelm
AU - Thygesen, Lau Caspar
AU - Miranda, Maria Jose
N1 - Publisher Copyright:
© 2022 European Paediatric Neurology Society
PY - 2023
Y1 - 2023
N2 - The aim was to determine school performance and psychiatric comorbidity in children with childhood absence epilepsy (CAE). We reviewed the medical records in children with ICD-10 codes for idiopathic generalized epilepsy before 18 years of age, and pediatric neurologists confirmed the International League Against Epilepsy criteria for CAE were met. Control groups were the general pediatric population or children with non-neurological chronic disease. Outcomes were from nationwide and population-based registers on school performance and psychiatric comorbidity. We compared the mean grade point average using linear regression and estimated hazard ratios (HR) using Cox regression for the other outcomes. Analyses were adjusted for the child's sex, and year of birth, and parental highest education, receipt of cash benefits or early disability pension. We included 114 children with CAE with a median age at onset of 5.9 years (interquartile range = 4.5–7.3 years). Compared with both population controls and non-neurological chronically ill children, children with CAE had increased hazard of special needs education (HR = 2.7, 95% confidence interval (CI) = 1.8–4.1, p < 0.0001), lower grade point average at 9th grade by 1.7 grade points (95% CI = -2.5 to -1.0, p < 0.001), increased ADHD medicine use (HR = 4.4, 95% CI = 2.7–7.2, p < 0.001), increased sleep medicine use (HR 2.7, 95% CI = 1.7–4.3, p < 0.001), and increased psychiatry visits (HR = 2.1; 95% CI = 1.1–4.0; p = 0.03). In conclusion, children with CAE have increased psychiatric comorbidity and a considerable proportion of these children receive special needs education in primary/secondary school, albeit insufficient to normalize their considerably lower grade point average in the 9th grade.
AB - The aim was to determine school performance and psychiatric comorbidity in children with childhood absence epilepsy (CAE). We reviewed the medical records in children with ICD-10 codes for idiopathic generalized epilepsy before 18 years of age, and pediatric neurologists confirmed the International League Against Epilepsy criteria for CAE were met. Control groups were the general pediatric population or children with non-neurological chronic disease. Outcomes were from nationwide and population-based registers on school performance and psychiatric comorbidity. We compared the mean grade point average using linear regression and estimated hazard ratios (HR) using Cox regression for the other outcomes. Analyses were adjusted for the child's sex, and year of birth, and parental highest education, receipt of cash benefits or early disability pension. We included 114 children with CAE with a median age at onset of 5.9 years (interquartile range = 4.5–7.3 years). Compared with both population controls and non-neurological chronically ill children, children with CAE had increased hazard of special needs education (HR = 2.7, 95% confidence interval (CI) = 1.8–4.1, p < 0.0001), lower grade point average at 9th grade by 1.7 grade points (95% CI = -2.5 to -1.0, p < 0.001), increased ADHD medicine use (HR = 4.4, 95% CI = 2.7–7.2, p < 0.001), increased sleep medicine use (HR 2.7, 95% CI = 1.7–4.3, p < 0.001), and increased psychiatry visits (HR = 2.1; 95% CI = 1.1–4.0; p = 0.03). In conclusion, children with CAE have increased psychiatric comorbidity and a considerable proportion of these children receive special needs education in primary/secondary school, albeit insufficient to normalize their considerably lower grade point average in the 9th grade.
KW - ADHD
KW - Childhood absence epilepsy
KW - Prognosis
KW - Psychiatric comorbidity
KW - School
U2 - 10.1016/j.ejpn.2022.12.008
DO - 10.1016/j.ejpn.2022.12.008
M3 - Journal article
C2 - 36584475
AN - SCOPUS:85145318778
VL - 42
SP - 75
EP - 81
JO - European Journal of Paediatric Neurology
JF - European Journal of Paediatric Neurology
SN - 1090-3798
ER -