Screen for CACNA1A and ATP1A2 mutations in sporadic hemiplegic migraine patients

L.L. Thomsen, E. Oestergaard, A. Bjornsson, H. Stefansson, A.C. Fasquel, J. Gulcher, K. Stefansson, J. Olesen

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    Abstract

    The aim of this study was to investigate the involvement of the CACNA1A and ATP1A2 gene in a population-based sample of sporadic hemiplegic migraine (SHM). Patients with SHM (n = 105) were identified in a nationwide search in the Danish population. We sequenced all exons and promoter regions of the CACNA1A and ATP1A2 genes in 100 patients with SHM to search for possible SHM mutations. Novel DNA variants were discovered in eight SHM patients, four in exons of the CACNA1A gene and four in exons of the ATP1A2 gene. Six of the variants were considered non-pathogenic. The causal role of the two remaining DNA variants is unknown until functional studies have been made or independent genetic evidence is discovered. Only very few DNA variants were identified in 100 SHM patients, and regardless of whether the identified variants are causal the CACNA1A and ATP1A2 genes are not major genes in SHM
    Udgivelsesdato: 2008/9
    Original languageEnglish
    JournalCephalalgia
    Volume28
    Issue number9
    Pages (from-to)914-921
    Number of pages7
    ISSN0333-1024
    Publication statusPublished - 2008

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