Abstract
Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
| Original language | English |
|---|---|
| Journal | Nature Medicine |
| Volume | 29 |
| Issue number | 10 |
| Pages (from-to) | 2438-2457 |
| Number of pages | 20 |
| ISSN | 1078-8956 |
| DOIs | |
| Publication status | Published - 2023 |
Bibliographical note
Publisher Copyright:© 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.
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Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine. / Tobias, Deirdre K.; Merino, Jordi; Ahmad, Abrar; Aiken, Catherine; Benham, Jamie L.; Bodhini, Dhanasekaran; Clark, Amy L.; Colclough, Kevin; Corcoy, Rosa; Cromer, Sara J.; Duan, Daisy; Felton, Jamie L.; Francis, Ellen C.; Gillard, Pieter; Gingras, Véronique; Gaillard, Romy; Haider, Eram; Hughes, Alice; Ikle, Jennifer M.; Jacobsen, Laura M.; Kahkoska, Anna R.; Kettunen, Jarno L.T.; Kreienkamp, Raymond J.; Lim, Lee Ling; Männistö, Jonna M.E.; Massey, Robert; Mclennan, Niamh Maire; Miller, Rachel G.; Morieri, Mario Luca; Most, Jasper; Naylor, Rochelle N.; Ozkan, Bige; Patel, Kashyap Amratlal; Pilla, Scott J.; Prystupa, Katsiaryna; Raghavan, Sridharan; Rooney, Mary R.; Schön, Martin; Semnani-Azad, Zhila; Sevilla-Gonzalez, Magdalena; Svalastoga, Pernille; Takele, Wubet Worku; Tam, Claudia Ha ting; Thuesen, Anne Cathrine B.; Tosur, Mustafa; Wallace, Amelia S.; Wang, Caroline C.; Wong, Jessie J.; Yamamoto, Jennifer M.; Young, Katherine; Amouyal, Chloé; Andersen, Mette K.; Bonham, Maxine P.; Chen, Mingling; Cheng, Feifei; Chikowore, Tinashe; Chivers, Sian C.; Clemmensen, Christoffer; Dabelea, Dana; Dawed, Adem Y.; Deutsch, Aaron J.; Dickens, Laura T.; DiMeglio, Linda A.; Dudenhöffer-Pfeifer, Monika; Evans-Molina, Carmella; Fernández-Balsells, María Mercè; Fitipaldi, Hugo; Fitzpatrick, Stephanie L.; Gitelman, Stephen E.; Goodarzi, Mark O.; Grieger, Jessica A.; Guasch-Ferré, Marta; Habibi, Nahal; Hansen, Torben; Huang, Chuiguo; Harris-Kawano, Arianna; Ismail, Heba M.; Hoag, Benjamin; Johnson, Randi K.; Jones, Angus G.; Koivula, Robert W.; Leong, Aaron; Leung, Gloria K.W.; Libman, Ingrid M.; Liu, Kai; Long, S. Alice; Lowe, William L.; Morton, Robert W.; Motala, Ayesha A.; Onengut-Gumuscu, Suna; Pankow, James S.; Pathirana, Maleesa; Pazmino, Sofia; Perez, Dianna; Petrie, John R.; Powe, Camille E.; Quinteros, Alejandra; Jain, Rashmi; Ray, Debashree; Ried-Larsen, Mathias; Saeed, Zeb; Santhakumar, Vanessa; Kanbour, Sarah; Sarkar, Sudipa; Monaco, Gabriela S.F.; Scholtens, Denise M.; Selvin, Elizabeth; Sheu, Wayne Huey Herng; Speake, Cate; Stanislawski, Maggie A.; Steenackers, Nele; Steck, Andrea K.; Stefan, Norbert; Støy, Julie; Taylor, Rachael; Tye, Sok Cin; Ukke, Gebresilasea Gendisha; Urazbayeva, Marzhan; Van der Schueren, Bart; Vatier, Camille; Wentworth, John M.; Hannah, Wesley; White, Sara L.; Yu, Gechang; Zhang, Yingchai; Zhou, Shao J.; Beltrand, Jacques; Polak, Michel; Aukrust, Ingvild; de Franco, Elisa; Flanagan, Sarah E.; Maloney, Kristin A.; McGovern, Andrew; Molnes, Janne; Nakabuye, Mariam; Njølstad, Pål Rasmus; Pomares-Millan, Hugo; Provenzano, Michele; Saint-Martin, Cécile; Zhang, Cuilin; Zhu, Yeyi; Auh, Sungyoung; de Souza, Russell; Fawcett, Andrea J.; Gruber, Chandra; Mekonnen, Eskedar Getie; Mixter, Emily; Sherifali, Diana; Eckel, Robert H.; Nolan, John J.; Philipson, Louis H.; Brown, Rebecca J.; Billings, Liana K.; Boyle, Kristen; Costacou, Tina; Dennis, John M.; Florez, Jose C.; Gloyn, Anna L.; Gomez, Maria F.; Gottlieb, Peter A.; Greeley, Siri Atma W.; Griffin, Kurt; Hattersley, Andrew T.; Hirsch, Irl B.; Hivert, Marie France; Hood, Korey K.; Josefson, Jami L.; Kwak, Soo Heon; Laffel, Lori M.; Lim, Siew S.; Loos, Ruth J.F.; Ma, Ronald C.W.; Mathieu, Chantal; Mathioudakis, Nestoras; Meigs, James B.; Misra, Shivani; Mohan, Viswanathan; Murphy, Rinki; Oram, Richard; Owen, Katharine R.; Ozanne, Susan E.; Pearson, Ewan R.; Perng, Wei; Pollin, Toni I.; Pop-Busui, Rodica; Pratley, Richard E.; Redman, Leanne M.; Redondo, Maria J.; Reynolds, Rebecca M.; Semple, Robert K.; Sherr, Jennifer L.; Sims, Emily K.; Sweeting, Arianne; Tuomi, Tiinamaija; Udler, Miriam S.; Vesco, Kimberly K.; Vilsbøll, Tina; Wagner, Robert; Rich, Stephen S.; Franks, Paul W.
In: Nature Medicine, Vol. 29, No. 10, 2023, p. 2438-2457.Research output: Contribution to journal › Journal article › Research › peer-review
}
TY - JOUR
T1 - Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
AU - Tobias, Deirdre K.
AU - Merino, Jordi
AU - Ahmad, Abrar
AU - Aiken, Catherine
AU - Benham, Jamie L.
AU - Bodhini, Dhanasekaran
AU - Clark, Amy L.
AU - Colclough, Kevin
AU - Corcoy, Rosa
AU - Cromer, Sara J.
AU - Duan, Daisy
AU - Felton, Jamie L.
AU - Francis, Ellen C.
AU - Gillard, Pieter
AU - Gingras, Véronique
AU - Gaillard, Romy
AU - Haider, Eram
AU - Hughes, Alice
AU - Ikle, Jennifer M.
AU - Jacobsen, Laura M.
AU - Kahkoska, Anna R.
AU - Kettunen, Jarno L.T.
AU - Kreienkamp, Raymond J.
AU - Lim, Lee Ling
AU - Männistö, Jonna M.E.
AU - Massey, Robert
AU - Mclennan, Niamh Maire
AU - Miller, Rachel G.
AU - Morieri, Mario Luca
AU - Most, Jasper
AU - Naylor, Rochelle N.
AU - Ozkan, Bige
AU - Patel, Kashyap Amratlal
AU - Pilla, Scott J.
AU - Prystupa, Katsiaryna
AU - Raghavan, Sridharan
AU - Rooney, Mary R.
AU - Schön, Martin
AU - Semnani-Azad, Zhila
AU - Sevilla-Gonzalez, Magdalena
AU - Svalastoga, Pernille
AU - Takele, Wubet Worku
AU - Tam, Claudia Ha ting
AU - Thuesen, Anne Cathrine B.
AU - Tosur, Mustafa
AU - Wallace, Amelia S.
AU - Wang, Caroline C.
AU - Wong, Jessie J.
AU - Yamamoto, Jennifer M.
AU - Young, Katherine
AU - Amouyal, Chloé
AU - Andersen, Mette K.
AU - Bonham, Maxine P.
AU - Chen, Mingling
AU - Cheng, Feifei
AU - Chikowore, Tinashe
AU - Chivers, Sian C.
AU - Clemmensen, Christoffer
AU - Dabelea, Dana
AU - Dawed, Adem Y.
AU - Deutsch, Aaron J.
AU - Dickens, Laura T.
AU - DiMeglio, Linda A.
AU - Dudenhöffer-Pfeifer, Monika
AU - Evans-Molina, Carmella
AU - Fernández-Balsells, María Mercè
AU - Fitipaldi, Hugo
AU - Fitzpatrick, Stephanie L.
AU - Gitelman, Stephen E.
AU - Goodarzi, Mark O.
AU - Grieger, Jessica A.
AU - Guasch-Ferré, Marta
AU - Habibi, Nahal
AU - Hansen, Torben
AU - Huang, Chuiguo
AU - Harris-Kawano, Arianna
AU - Ismail, Heba M.
AU - Hoag, Benjamin
AU - Johnson, Randi K.
AU - Jones, Angus G.
AU - Koivula, Robert W.
AU - Leong, Aaron
AU - Leung, Gloria K.W.
AU - Libman, Ingrid M.
AU - Liu, Kai
AU - Long, S. Alice
AU - Lowe, William L.
AU - Morton, Robert W.
AU - Motala, Ayesha A.
AU - Onengut-Gumuscu, Suna
AU - Pankow, James S.
AU - Pathirana, Maleesa
AU - Pazmino, Sofia
AU - Perez, Dianna
AU - Petrie, John R.
AU - Powe, Camille E.
AU - Quinteros, Alejandra
AU - Jain, Rashmi
AU - Ray, Debashree
AU - Ried-Larsen, Mathias
AU - Saeed, Zeb
AU - Santhakumar, Vanessa
AU - Kanbour, Sarah
AU - Sarkar, Sudipa
AU - Monaco, Gabriela S.F.
AU - Scholtens, Denise M.
AU - Selvin, Elizabeth
AU - Sheu, Wayne Huey Herng
AU - Speake, Cate
AU - Stanislawski, Maggie A.
AU - Steenackers, Nele
AU - Steck, Andrea K.
AU - Stefan, Norbert
AU - Støy, Julie
AU - Taylor, Rachael
AU - Tye, Sok Cin
AU - Ukke, Gebresilasea Gendisha
AU - Urazbayeva, Marzhan
AU - Van der Schueren, Bart
AU - Vatier, Camille
AU - Wentworth, John M.
AU - Hannah, Wesley
AU - White, Sara L.
AU - Yu, Gechang
AU - Zhang, Yingchai
AU - Zhou, Shao J.
AU - Beltrand, Jacques
AU - Polak, Michel
AU - Aukrust, Ingvild
AU - de Franco, Elisa
AU - Flanagan, Sarah E.
AU - Maloney, Kristin A.
AU - McGovern, Andrew
AU - Molnes, Janne
AU - Nakabuye, Mariam
AU - Njølstad, Pål Rasmus
AU - Pomares-Millan, Hugo
AU - Provenzano, Michele
AU - Saint-Martin, Cécile
AU - Zhang, Cuilin
AU - Zhu, Yeyi
AU - Auh, Sungyoung
AU - de Souza, Russell
AU - Fawcett, Andrea J.
AU - Gruber, Chandra
AU - Mekonnen, Eskedar Getie
AU - Mixter, Emily
AU - Sherifali, Diana
AU - Eckel, Robert H.
AU - Nolan, John J.
AU - Philipson, Louis H.
AU - Brown, Rebecca J.
AU - Billings, Liana K.
AU - Boyle, Kristen
AU - Costacou, Tina
AU - Dennis, John M.
AU - Florez, Jose C.
AU - Gloyn, Anna L.
AU - Gomez, Maria F.
AU - Gottlieb, Peter A.
AU - Greeley, Siri Atma W.
AU - Griffin, Kurt
AU - Hattersley, Andrew T.
AU - Hirsch, Irl B.
AU - Hivert, Marie France
AU - Hood, Korey K.
AU - Josefson, Jami L.
AU - Kwak, Soo Heon
AU - Laffel, Lori M.
AU - Lim, Siew S.
AU - Loos, Ruth J.F.
AU - Ma, Ronald C.W.
AU - Mathieu, Chantal
AU - Mathioudakis, Nestoras
AU - Meigs, James B.
AU - Misra, Shivani
AU - Mohan, Viswanathan
AU - Murphy, Rinki
AU - Oram, Richard
AU - Owen, Katharine R.
AU - Ozanne, Susan E.
AU - Pearson, Ewan R.
AU - Perng, Wei
AU - Pollin, Toni I.
AU - Pop-Busui, Rodica
AU - Pratley, Richard E.
AU - Redman, Leanne M.
AU - Redondo, Maria J.
AU - Reynolds, Rebecca M.
AU - Semple, Robert K.
AU - Sherr, Jennifer L.
AU - Sims, Emily K.
AU - Sweeting, Arianne
AU - Tuomi, Tiinamaija
AU - Udler, Miriam S.
AU - Vesco, Kimberly K.
AU - Vilsbøll, Tina
AU - Wagner, Robert
AU - Rich, Stephen S.
AU - Franks, Paul W.
N1 - Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2023
Y1 - 2023
N2 - Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
AB - Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
U2 - 10.1038/s41591-023-02502-5
DO - 10.1038/s41591-023-02502-5
M3 - Journal article
C2 - 37794253
AN - SCOPUS:85173437266
VL - 29
SP - 2438
EP - 2457
JO - Nature Medicine
JF - Nature Medicine
SN - 1078-8956
IS - 10
ER -