TY - JOUR
T1 - Second primary cancers in pediatric head and neck cancer survivors in Denmark during 1980–2014
T2 - A nationwide study
AU - Schmidt Jensen, Jakob
AU - Grønhøj, Christian
AU - Ruud Kjær, Eva Kristine
AU - Charabi, Birgitte Wittenborg
AU - von Buchwald, Christian
AU - Hjuler, Thomas
PY - 2019/12
Y1 - 2019/12
N2 - Introduction: The survival among children with cancer has improved considerably the past decades. Consequently, more children are at risk of second primary cancers (SPC). This study aimed to investigate the incidence of SPC among pediatric head and neck cancer (HNC) patients. Methods and materials: Data on children aged 0–17 years registered with a HNC in the Danish Registry of Childhood Cancer and the Danish National Patient Registry during the period 1980–2014 was obtained. SPC was defined as registration with any second malignancy that was not simultaneous with the first primary cancer (FPC) or a relapse hereof. All information was validated through review of medical charts. Standardized incidence rates (SIR) were calculated using the average incidence of all cancers in the general population of Denmark during the study period as reference. Results: Among 234 pediatric HNC patients, six patients (four females) were registered with a SPC (2.6%), corresponding to an overall SIR of 4.8. No patients were diagnosed with more than one SPC. The median age at FPC and SPC was 15.2 years (range 9–16 years) and 35.0 years (range 19–41 years). The most common tumor histology and location among the patients with SPC was nasopharyngeal lymphoepithelial carcinoma for FPC and basal cell carcinoma of the skin for SPC. Conclusion: During 1980–2014 we identified six cases of SPC among 234 pediatric head and neck cancer patients in Denmark, corresponding to an overall SIR of 4.8.
AB - Introduction: The survival among children with cancer has improved considerably the past decades. Consequently, more children are at risk of second primary cancers (SPC). This study aimed to investigate the incidence of SPC among pediatric head and neck cancer (HNC) patients. Methods and materials: Data on children aged 0–17 years registered with a HNC in the Danish Registry of Childhood Cancer and the Danish National Patient Registry during the period 1980–2014 was obtained. SPC was defined as registration with any second malignancy that was not simultaneous with the first primary cancer (FPC) or a relapse hereof. All information was validated through review of medical charts. Standardized incidence rates (SIR) were calculated using the average incidence of all cancers in the general population of Denmark during the study period as reference. Results: Among 234 pediatric HNC patients, six patients (four females) were registered with a SPC (2.6%), corresponding to an overall SIR of 4.8. No patients were diagnosed with more than one SPC. The median age at FPC and SPC was 15.2 years (range 9–16 years) and 35.0 years (range 19–41 years). The most common tumor histology and location among the patients with SPC was nasopharyngeal lymphoepithelial carcinoma for FPC and basal cell carcinoma of the skin for SPC. Conclusion: During 1980–2014 we identified six cases of SPC among 234 pediatric head and neck cancer patients in Denmark, corresponding to an overall SIR of 4.8.
KW - Head and neck cancer
KW - Incidence
KW - Nation-wide study
KW - Pediatric
KW - Second primary cancer
UR - http://www.scopus.com/inward/record.url?scp=85071291476&partnerID=8YFLogxK
U2 - 10.1016/j.ijporl.2019.109648
DO - 10.1016/j.ijporl.2019.109648
M3 - Journal article
C2 - 31472358
AN - SCOPUS:85071291476
VL - 127
JO - International Journal of Pediatric Otorhinolaryngology Extra
JF - International Journal of Pediatric Otorhinolaryngology Extra
SN - 1871-4048
M1 - 109648
ER -