Segmental reversal of the distal small intestine in a short bowel syndrome model in piglets showed detrimental effect on weight gain

Lasse Hartmann Schmidt*, Jesper Stensig Aa, Bolette Hartmann, Gunvor Iben Madsen, Niels Qvist, Mark Bremholm Ellebæk

*Corresponding author for this work

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Abstract

Background: To investigate the effects of a reversed segment of the distal small intestine to improve weight gain in an experimental short bowel syndrome (SBS) model in piglets. Methods: Twenty-four piglets underwent resection of 70% of the distal small intestine. In half of the animals a conventional anastomosis was performed, and in the other half, the distal 25 cm of the remnant jejunum was reversed before the intestinal continuity was recreated. Weight was measured daily until day 28, where the animals were euthanized. Glucagon-Like Peptide-2 (GLP-2) and Glucose-dependent Insulinotropic Peptide (GIP) was measured pre- and postoperatively at day 28. Results: The group with reversal of small intestine had a significant lower weight gain at 5.26 ± 3.39 kg (mean ± SD) compared to the control group with 11.14 ± 3.83 kg (p < 0.05). In the control group greater villus height and crypt depth was found distally, and greater muscular thickness was found proximally in the intervention group. GLP-2 and GIP levels increased significantly in the control group. Conclusions: Treatment of short bowel syndrome with a reversed jejunal segment of 25 cm had a detrimental effect on the weight gain.

Original languageEnglish
Article number349
JournalBMC Gastroenterology
Volume22
Issue number1
Number of pages9
ISSN1471-230X
DOIs
Publication statusPublished - 2022

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© 2022, The Author(s).

Keywords

  • GIP
  • GLP-2
  • Segmental reversal
  • Short bowel syndrome
  • Short gut syndrome

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