Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat.

Flemming Fryd Johansen; M B Jørgensen; D K Ekström von Lubitz; N H Diemer

Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat.

Flemming Fryd Johansen, M B Jørgensen, D K Ekström von Lubitz, N H Diemer

Research output: Contribution to journal › Journal article › Research › peer-review

97 Citations (Scopus)

Abstract

In this study of the rat hippocampal CA1 stratum radiatum 4 days after 20 min transient cerebral ischaemia, we demonstrated ultrastructural dendritic degeneration and loss, whereas most axons appeared undamaged. Autoradiographs 4 days after ischaemia showed unchanged Na+-dependent glutamate high affinity uptake. The role of glutamate and Ca2+ for this selective postsynaptic vulnerability is discussed.

Original language	English
Journal	Brain Research
Volume	291
Issue number	2
Pages (from-to)	373-7
Number of pages	4
ISSN	0006-8993
Publication status	Published - 1984
Externally published	Yes

Bibliographical note

Keywords: Animals; Axons; Calcium; Dendrites; Glutamates; Glutamic Acid; Hippocampus; Ischemic Attack, Transient; Male; Microscopy, Electron; Rats; Rats, Inbred Strains

Cite this

Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat. / Johansen, Flemming Fryd; Jørgensen, M B; Ekström von Lubitz, D K et al.
In: Brain Research, Vol. 291, No. 2, 1984, p. 373-7.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "In this study of the rat hippocampal CA1 stratum radiatum 4 days after 20 min transient cerebral ischaemia, we demonstrated ultrastructural dendritic degeneration and loss, whereas most axons appeared undamaged. Autoradiographs 4 days after ischaemia showed unchanged Na+-dependent glutamate high affinity uptake. The role of glutamate and Ca2+ for this selective postsynaptic vulnerability is discussed.",

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AU - Jørgensen, M B

AU - Ekström von Lubitz, D K

AU - Diemer, N H

N1 - Keywords: Animals; Axons; Calcium; Dendrites; Glutamates; Glutamic Acid; Hippocampus; Ischemic Attack, Transient; Male; Microscopy, Electron; Rats; Rats, Inbred Strains

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N2 - In this study of the rat hippocampal CA1 stratum radiatum 4 days after 20 min transient cerebral ischaemia, we demonstrated ultrastructural dendritic degeneration and loss, whereas most axons appeared undamaged. Autoradiographs 4 days after ischaemia showed unchanged Na+-dependent glutamate high affinity uptake. The role of glutamate and Ca2+ for this selective postsynaptic vulnerability is discussed.

AB - In this study of the rat hippocampal CA1 stratum radiatum 4 days after 20 min transient cerebral ischaemia, we demonstrated ultrastructural dendritic degeneration and loss, whereas most axons appeared undamaged. Autoradiographs 4 days after ischaemia showed unchanged Na+-dependent glutamate high affinity uptake. The role of glutamate and Ca2+ for this selective postsynaptic vulnerability is discussed.

M3 - Journal article

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