Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits

Jens U Marquardt; Daekwan Seo; Jesper Bøje Andersen; Matthew C Gillen; Myoung Soo Kim; Elizabeth A Conner; Peter R Galle; Valentina M Factor; Young Nyun Park; Snorri S Thorgeirsson

doi:10.1016/j.jhep.2013.10.014

Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits

Jens U Marquardt, Daekwan Seo, Jesper Bøje Andersen, Matthew C Gillen, Myoung Soo Kim, Elizabeth A Conner, Peter R Galle, Valentina M Factor, Young Nyun Park, Snorri S Thorgeirsson

Research output: Contribution to journal › Journal article › Research › peer-review

83 Citations (Scopus)

Abstract

Human hepatocarcinogenesis is as a multi-step process starting from dysplastic lesions to early carcinomas (eHCC) that ultimately progress to HCC (pHCC). However, the sequential molecular alterations driving malignant transformation of the pre-neoplastic lesions are not clearly defined. This lack of information represents a major challenge in the clinical management of patients at risk.

Original language	English
Journal	Journal of Hepatology
Volume	60
Issue number	2
Pages (from-to)	346-53
Number of pages	8
ISSN	0168-8278
DOIs	https://doi.org/10.1016/j.jhep.2013.10.014
Publication status	Published - Feb 2014
Externally published	Yes

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Cite this

@article{dc44fb1114d54f9aae3afbda5996b853,

title = "Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits",

abstract = "Human hepatocarcinogenesis is as a multi-step process starting from dysplastic lesions to early carcinomas (eHCC) that ultimately progress to HCC (pHCC). However, the sequential molecular alterations driving malignant transformation of the pre-neoplastic lesions are not clearly defined. This lack of information represents a major challenge in the clinical management of patients at risk.",

author = "Marquardt, {Jens U} and Daekwan Seo and Andersen, {Jesper B{\o}je} and Gillen, {Matthew C} and Kim, {Myoung Soo} and Conner, {Elizabeth A} and Galle, {Peter R} and Factor, {Valentina M} and Park, {Young Nyun} and Thorgeirsson, {Snorri S}",

year = "2014",

month = feb,

doi = "10.1016/j.jhep.2013.10.014",

language = "English",

volume = "60",

pages = "346--53",

journal = "Journal of Hepatology",

issn = "0168-8278",

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number = "2",

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T1 - Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits

AU - Marquardt, Jens U

AU - Seo, Daekwan

AU - Andersen, Jesper Bøje

AU - Gillen, Matthew C

AU - Kim, Myoung Soo

AU - Conner, Elizabeth A

AU - Galle, Peter R

AU - Factor, Valentina M

AU - Park, Young Nyun

AU - Thorgeirsson, Snorri S

PY - 2014/2

Y1 - 2014/2

N2 - Human hepatocarcinogenesis is as a multi-step process starting from dysplastic lesions to early carcinomas (eHCC) that ultimately progress to HCC (pHCC). However, the sequential molecular alterations driving malignant transformation of the pre-neoplastic lesions are not clearly defined. This lack of information represents a major challenge in the clinical management of patients at risk.

AB - Human hepatocarcinogenesis is as a multi-step process starting from dysplastic lesions to early carcinomas (eHCC) that ultimately progress to HCC (pHCC). However, the sequential molecular alterations driving malignant transformation of the pre-neoplastic lesions are not clearly defined. This lack of information represents a major challenge in the clinical management of patients at risk.

U2 - 10.1016/j.jhep.2013.10.014

DO - 10.1016/j.jhep.2013.10.014

M3 - Journal article

C2 - 24512821

SN - 0168-8278

VL - 60

SP - 346

EP - 353

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 2

ER -