Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro

Carsten Uhd Nielsen; Sidsel Balsgaard Frølund; S Abdulhadi; H Sari; L Langthaler; Mark Klitgaard Nøhr; M A Kall; B Brodin; R Holm

doi:10.1111/bph.12341

Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro

Carsten Uhd Nielsen, Sidsel Balsgaard Frølund, S Abdulhadi, H Sari, L Langthaler, Mark Klitgaard Nøhr, M A Kall, B Brodin, R Holm

Pharmaceutical Design and Drug Delivery

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Abstract

Intestinal nutrient transporters may mediate the uptake of drugs. The aim of this study was to investigate whether sertraline interacts with the intestinal proton-coupled amino acid transporter 1 PAT1 (SLC36A1).

Original language	English
Journal	British Journal of Pharmacology
Volume	170
Issue number	5
Pages (from-to)	1041-52
Number of pages	12
ISSN	0007-1188
DOIs	https://doi.org/10.1111/bph.12341
Publication status	Published - Nov 2013

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10.1111/bph.12341

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Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro. / Nielsen, Carsten Uhd; Frølund, Sidsel Balsgaard; Abdulhadi, S; Sari, H; Langthaler, L; Nøhr, Mark Klitgaard; Kall, M A; Brodin, B; Holm, R.

In: British Journal of Pharmacology, Vol. 170, No. 5, 11.2013, p. 1041-52.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Intestinal nutrient transporters may mediate the uptake of drugs. The aim of this study was to investigate whether sertraline interacts with the intestinal proton-coupled amino acid transporter 1 PAT1 (SLC36A1).",

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AU - Kall, M A

AU - Brodin, B

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