Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men

V P Garcia, J D Mattos, J Mentzinger, P E C Leite, H N M Rocha, M O Campos, M P Rocha, D E Mansur, Niels H. Secher, A C L Nóbrega, I A Fernandes, N G Rocha*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21% O2) and 10-min hyperoxia trials (100% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia: 4.16±0.85 vs normoxia: 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia: 8.40±3.84 vs normoxia: 5.73±2.15 pg/mL, P=0.04) increased, whereas matrix
metalloproteinase (MMP-9) activity (hyperoxia: 0.53±0.11 vs normoxia: 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100% oxygen may affect endothelial activation and vascular remodeling.
Original languageEnglish
Article numbere12110
JournalBrazilian Journal of Medical and Biological Research
Volume55
Number of pages6
ISSN0100-879X
DOIs
Publication statusPublished - 2022

Keywords

  • Faculty of Science
  • Endothelium
  • Hyperoxia
  • ICAM-1
  • Metalloproteinase-9
  • Vascular remodeling

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