Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon

K V Haderslev, P B Jeppesen, B Hartmann, J Thulesen, H A Sorensen, J Graff, F Tofteng, S S Poulsen, J L Madsen, J J Holst, M Staun, P B Mortensen, Steen Seier Poulsen

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Abstract

Glucagon-like peptide 2 (GLP-2) is a newly discovered intestinotrophic hormone. We have recently reported that a 5-week GLP-2 treatment improved the intestinal absorptive capacity of short-bowel patients with no colon. Additionally, GLP-2 treatment was associated with changes in body composition that included a significant increase in total body bone mass. This article describes the effect of GLP-2 on spinal and hip bone mineral density (BMD) and biochemical markers of bone turnover in these patients.
Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Volume37
Issue number4
Pages (from-to)392-8
Number of pages7
ISSN0036-5521
Publication statusPublished - 1 Apr 2002

Keywords

  • Absorptiometry, Photon
  • Adult
  • Alkaline Phosphatase
  • Amino Acids
  • Bone Density
  • Bone Diseases, Metabolic
  • Bone Remodeling
  • Calcium
  • Female
  • Gastrointestinal Hormones
  • Glucagon
  • Glucagon-Like Peptide 2
  • Glucagon-Like Peptides
  • Hormones
  • Humans
  • Intestinal Absorption
  • Male
  • Middle Aged
  • Osteocalcin
  • Osteoporosis
  • Parathyroid Hormone
  • Peptides
  • Pilot Projects
  • Short Bowel Syndrome
  • Vitamin D

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