SignalP: The Evolution of a Web Server

Henrik Nielsen; Felix Teufel; Søren Brunak; Gunnar von Heijne

doi:10.1007/978-1-0716-4007-4_17

SignalP: The Evolution of a Web Server

Henrik Nielsen, Felix Teufel, Søren Brunak, Gunnar von Heijne

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

7 Citations (Scopus)

Abstract

SignalP ( https://services.healthtech.dtu.dk/services/SignalP-6.0/ ) is a very popular prediction method for signal peptides, the intrinsic signals that make proteins secretory. The SignalP web server has existed since 1995 and is now in its sixth major version. In this historical account, we (three authors who have taken part in the entire journey plus the first author of the latest version) describe the differences between the versions and discuss the various decisions taken along the way.

Original language	English
Title of host publication	Protein Bioinformatics
Editors	Frédérique Lisacek
Number of pages	37
Volume	2836
Publication date	2024
Pages	331-367
Chapter	17
DOIs	https://doi.org/10.1007/978-1-0716-4007-4_17
Publication status	Published - 2024

Series	Methods in molecular biology (Clifton, N.J.)
ISSN	1064-3745

Bibliographical note

Publisher Copyright:
© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

Hidden Markov model
Neural network
Protein language model
Signal peptide

Access to Document

10.1007/978-1-0716-4007-4_17

FulltextFinal published version, 1.49 MB

Cite this

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