Silver carbene complexes: An emerging class of anticancer agents

Shravankumar Kankala; Niranjan Thota; Fredrik Björkling; Myles K Taylor; Ravinder Vadde; Ramesh Balusu

doi:10.1002/ddr.21478

Silver carbene complexes: An emerging class of anticancer agents

Shravankumar Kankala, Niranjan Thota, Fredrik Björkling, Myles K Taylor, Ravinder Vadde, Ramesh Balusu

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

Abstract

Hit, Lead & Candidate Discovery Cancer is a major global health problem with large therapeutic challenges. Although substantial progress has been made in cancer therapy, there still remains a need to develop novel and effective treatment strategies to treat several relapsed and refractory cancers. Recently, there has been growing demand for considering organometallics as antineoplastic agents. This review is focused on a group of organometallics, silver N-heterocyclic carbene complexes (SCCs) and their anticancer efficacy in targeting multiple pathways in various in vitro cancer model systems. However, the precise molecular mechanism of SCCs anticancer properties remains unclear. Here, we discuss the SCCs chemistry, potential molecular targets, possible molecular mechanism of action, and their application in cancer therapies.

Original language	English
Journal	Drug Development Research
Volume	80
Issue number	2
Pages (from-to)	188-199
ISSN	0272-4391
DOIs	https://doi.org/10.1002/ddr.21478
Publication status	Published - Mar 2019

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10.1002/ddr.21478

Cite this

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title = "Silver carbene complexes: An emerging class of anticancer agents",

abstract = "Hit, Lead & Candidate Discovery Cancer is a major global health problem with large therapeutic challenges. Although substantial progress has been made in cancer therapy, there still remains a need to develop novel and effective treatment strategies to treat several relapsed and refractory cancers. Recently, there has been growing demand for considering organometallics as antineoplastic agents. This review is focused on a group of organometallics, silver N-heterocyclic carbene complexes (SCCs) and their anticancer efficacy in targeting multiple pathways in various in vitro cancer model systems. However, the precise molecular mechanism of SCCs anticancer properties remains unclear. Here, we discuss the SCCs chemistry, potential molecular targets, possible molecular mechanism of action, and their application in cancer therapies.",

author = "Shravankumar Kankala and Niranjan Thota and Fredrik Bj{\"o}rkling and Taylor, {Myles K} and Ravinder Vadde and Ramesh Balusu",

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T2 - An emerging class of anticancer agents

AU - Kankala, Shravankumar

AU - Thota, Niranjan

AU - Björkling, Fredrik

AU - Taylor, Myles K

AU - Vadde, Ravinder

AU - Balusu, Ramesh

PY - 2019/3

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N2 - Hit, Lead & Candidate Discovery Cancer is a major global health problem with large therapeutic challenges. Although substantial progress has been made in cancer therapy, there still remains a need to develop novel and effective treatment strategies to treat several relapsed and refractory cancers. Recently, there has been growing demand for considering organometallics as antineoplastic agents. This review is focused on a group of organometallics, silver N-heterocyclic carbene complexes (SCCs) and their anticancer efficacy in targeting multiple pathways in various in vitro cancer model systems. However, the precise molecular mechanism of SCCs anticancer properties remains unclear. Here, we discuss the SCCs chemistry, potential molecular targets, possible molecular mechanism of action, and their application in cancer therapies.

AB - Hit, Lead & Candidate Discovery Cancer is a major global health problem with large therapeutic challenges. Although substantial progress has been made in cancer therapy, there still remains a need to develop novel and effective treatment strategies to treat several relapsed and refractory cancers. Recently, there has been growing demand for considering organometallics as antineoplastic agents. This review is focused on a group of organometallics, silver N-heterocyclic carbene complexes (SCCs) and their anticancer efficacy in targeting multiple pathways in various in vitro cancer model systems. However, the precise molecular mechanism of SCCs anticancer properties remains unclear. Here, we discuss the SCCs chemistry, potential molecular targets, possible molecular mechanism of action, and their application in cancer therapies.

U2 - 10.1002/ddr.21478

DO - 10.1002/ddr.21478

M3 - Journal article

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VL - 80

SP - 188

EP - 199

JO - Drug Development Research

JF - Drug Development Research

SN - 0272-4391

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