Simulating realistic membrane shapes

Weria Pezeshkian; Siewert J. Marrink

doi:10.1016/j.ceb.2021.02.009

Simulating realistic membrane shapes

Weria Pezeshkian, Siewert J. Marrink^*

^*Corresponding author for this work

Research output: Contribution to journal › Review › Research › peer-review

42 Citations (Scopus)

10 Downloads (Pure)

Abstract

Biological membranes exhibit diversity in their shapes and complexity in chemical compositions that are linked to many cellular functions. These two central features of biomembranes have been the subject of numerous simulation studies, using a diverse range of computational techniques. Currently, the field is able to capture this complexity at increasing levels of realism and connect the microscopic view on protein-lipid interactions to cellular morphologies at the level of entire organelles. Here we highlight recent advances in this topic, identify current bottlenecks, and sketch possible ways ahead.

Original language	English
Journal	Current Opinion in Cell Biology
Volume	71
Pages (from-to)	103-111
Number of pages	9
ISSN	0955-0674
DOIs	https://doi.org/10.1016/j.ceb.2021.02.009
Publication status	Published - 1 Aug 2021
Externally published	Yes

Keywords

Membrane curvature
Multiscale simulations
Organelle shape
Mesoscale models
Molecular dynamics
Cell membranes
CURVATURE
PARTICLES

Access to Document

10.1016/j.ceb.2021.02.009Licence: CC BY

1-s2.0-S0955067421000302-mainFinal published version, 1.45 MBLicence: CC BY

Cite this

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abstract = "Biological membranes exhibit diversity in their shapes and complexity in chemical compositions that are linked to many cellular functions. These two central features of biomembranes have been the subject of numerous simulation studies, using a diverse range of computational techniques. Currently, the field is able to capture this complexity at increasing levels of realism and connect the microscopic view on protein-lipid interactions to cellular morphologies at the level of entire organelles. Here we highlight recent advances in this topic, identify current bottlenecks, and sketch possible ways ahead.",

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AU - Marrink, Siewert J.

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AB - Biological membranes exhibit diversity in their shapes and complexity in chemical compositions that are linked to many cellular functions. These two central features of biomembranes have been the subject of numerous simulation studies, using a diverse range of computational techniques. Currently, the field is able to capture this complexity at increasing levels of realism and connect the microscopic view on protein-lipid interactions to cellular morphologies at the level of entire organelles. Here we highlight recent advances in this topic, identify current bottlenecks, and sketch possible ways ahead.

KW - Membrane curvature

KW - Multiscale simulations

KW - Organelle shape

KW - Mesoscale models

KW - Molecular dynamics

KW - Cell membranes

KW - CURVATURE

KW - PARTICLES

U2 - 10.1016/j.ceb.2021.02.009

DO - 10.1016/j.ceb.2021.02.009

M3 - Review

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JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

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