Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance

Steen Larsen; Nis Stride; Martin Hey-Mogensen; Christina N Hansen; Lia E Bang; Henning Bundgaard; Lars B Nielsen; Jørn W Helge; Flemming Dela

doi:10.1016/j.jacc.2012.09.036

Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance

Steen Larsen, Nis Stride, Martin Hey-Mogensen, Christina N Hansen, Lia E Bang, Henning Bundgaard, Lars B Nielsen, Jørn W Helge, Flemming Dela

Research output: Contribution to journal › Journal article › Research › peer-review

153 Citations (Scopus)

Abstract

Glucose tolerance and skeletal muscle coenzyme Q(10) (Q(10)) content, mitochondrial density, and mitochondrial oxidative phosphorylation (OXPHOS) capacity were measured in simvastatin-treated patients (n = 10) and in well-matched control subjects (n = 9).

Original language	English
Journal	Journal of the American College of Cardiology
Volume	61
Issue number	1
Pages (from-to)	44-53
Number of pages	10
ISSN	0735-1097
DOIs	https://doi.org/10.1016/j.jacc.2012.09.036
Publication status	Published - 8 Jan 2013

Keywords

Blood Glucose
Case-Control Studies
Cell Respiration
Electron Transport
Electron Transport Complex I
Electron Transport Complex II
Glucose Intolerance
Glucose Tolerance Test
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Insulin Resistance
Male
Middle Aged
Mitochondria, Muscle
Muscle Fibers, Skeletal
Muscle, Skeletal
Oxidative Phosphorylation
Simvastatin
Ubiquinone

Access to Document

10.1016/j.jacc.2012.09.036

Cite this

Simvastatin effects on skeletal muscle : relation to decreased mitochondrial function and glucose intolerance. / Larsen, Steen; Stride, Nis; Hey-Mogensen, Martin; Hansen, Christina N; Bang, Lia E; Bundgaard, Henning; Nielsen, Lars B; Helge, Jørn W ; Dela, Flemming.

In: Journal of the American College of Cardiology, Vol. 61, No. 1, 08.01.2013, p. 44-53.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Glucose tolerance and skeletal muscle coenzyme Q(10) (Q(10)) content, mitochondrial density, and mitochondrial oxidative phosphorylation (OXPHOS) capacity were measured in simvastatin-treated patients (n = 10) and in well-matched control subjects (n = 9).",

keywords = "Blood Glucose, Case-Control Studies, Cell Respiration, Electron Transport, Electron Transport Complex I, Electron Transport Complex II, Glucose Intolerance, Glucose Tolerance Test, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Insulin Resistance, Male, Middle Aged, Mitochondria, Muscle, Muscle Fibers, Skeletal, Muscle, Skeletal, Oxidative Phosphorylation, Simvastatin, Ubiquinone",

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AU - Bang, Lia E

AU - Bundgaard, Henning

AU - Nielsen, Lars B

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