Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance

Steen Larsen; Nis Stride; Martin Hey-Mogensen; Christina N Hansen; Lia E Bang; Henning Bundgaard; Lars B Nielsen; Jørn W Helge; Flemming Dela

doi:10.1016/j.jacc.2012.09.036

Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance

Steen Larsen, Nis Stride, Martin Hey-Mogensen, Christina N Hansen, Lia E Bang, Henning Bundgaard, Lars B Nielsen, Jørn W Helge, Flemming Dela

Research output: Contribution to journal › Journal article › Research › peer-review

160 Citations (Scopus)

Abstract

Glucose tolerance and skeletal muscle coenzyme Q(10) (Q(10)) content, mitochondrial density, and mitochondrial oxidative phosphorylation (OXPHOS) capacity were measured in simvastatin-treated patients (n = 10) and in well-matched control subjects (n = 9).

Original language	English
Journal	Journal of the American College of Cardiology
Volume	61
Issue number	1
Pages (from-to)	44-53
Number of pages	10
ISSN	0735-1097
DOIs	https://doi.org/10.1016/j.jacc.2012.09.036
Publication status	Published - 8 Jan 2013

Keywords

Blood Glucose
Case-Control Studies
Cell Respiration
Electron Transport
Electron Transport Complex I
Electron Transport Complex II
Glucose Intolerance
Glucose Tolerance Test
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Insulin Resistance
Male
Middle Aged
Mitochondria, Muscle
Muscle Fibers, Skeletal
Muscle, Skeletal
Oxidative Phosphorylation
Simvastatin
Ubiquinone

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Cite this

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title = "Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance",

abstract = "Glucose tolerance and skeletal muscle coenzyme Q(10) (Q(10)) content, mitochondrial density, and mitochondrial oxidative phosphorylation (OXPHOS) capacity were measured in simvastatin-treated patients (n = 10) and in well-matched control subjects (n = 9).",

keywords = "Blood Glucose, Case-Control Studies, Cell Respiration, Electron Transport, Electron Transport Complex I, Electron Transport Complex II, Glucose Intolerance, Glucose Tolerance Test, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Insulin Resistance, Male, Middle Aged, Mitochondria, Muscle, Muscle Fibers, Skeletal, Muscle, Skeletal, Oxidative Phosphorylation, Simvastatin, Ubiquinone",

author = "Steen Larsen and Nis Stride and Martin Hey-Mogensen and Hansen, {Christina N} and Bang, {Lia E} and Henning Bundgaard and Nielsen, {Lars B} and Helge, {J{\o}rn W} and Flemming Dela",

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doi = "10.1016/j.jacc.2012.09.036",

language = "English",

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journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

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T1 - Simvastatin effects on skeletal muscle

T2 - relation to decreased mitochondrial function and glucose intolerance

AU - Larsen, Steen

AU - Stride, Nis

AU - Hey-Mogensen, Martin

AU - Hansen, Christina N

AU - Bang, Lia E

AU - Bundgaard, Henning

AU - Nielsen, Lars B

AU - Helge, Jørn W

AU - Dela, Flemming

PY - 2013/1/8

Y1 - 2013/1/8

N2 - Glucose tolerance and skeletal muscle coenzyme Q(10) (Q(10)) content, mitochondrial density, and mitochondrial oxidative phosphorylation (OXPHOS) capacity were measured in simvastatin-treated patients (n = 10) and in well-matched control subjects (n = 9).

AB - Glucose tolerance and skeletal muscle coenzyme Q(10) (Q(10)) content, mitochondrial density, and mitochondrial oxidative phosphorylation (OXPHOS) capacity were measured in simvastatin-treated patients (n = 10) and in well-matched control subjects (n = 9).

KW - Blood Glucose

KW - Case-Control Studies

KW - Cell Respiration

KW - Electron Transport

KW - Electron Transport Complex I

KW - Electron Transport Complex II

KW - Glucose Intolerance

KW - Glucose Tolerance Test

KW - Humans

KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors

KW - Insulin Resistance

KW - Male

KW - Middle Aged

KW - Mitochondria, Muscle

KW - Muscle Fibers, Skeletal

KW - Muscle, Skeletal

KW - Oxidative Phosphorylation

KW - Simvastatin

KW - Ubiquinone

U2 - 10.1016/j.jacc.2012.09.036

DO - 10.1016/j.jacc.2012.09.036

M3 - Journal article

C2 - 23287371

SN - 0735-1097

VL - 61

SP - 44

EP - 53

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 1

ER -