Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment

Stine D Ohlendorff, Charlotte L Tofteng, Jens-Erik B Jensen, Solveig Petersen, Roberto Civitelli, Mogens Fenger, Bo Abrahamsen, Anne P Hermann, Pia Agnete Eiken, Niklas R Jørgensen

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95 Citations (Scopus)

Abstract

The purinergic P2RX7 receptor (P2RX7) has been shown to play a role in the regulation of osteoblast and osteoclast activity. The aim of this study was to determine the presence of polymorphisms in exon 13 of the P2X7 gene and the association with osteoclast apoptosis in vitro and bone status in vivo.
Original languageEnglish
JournalPharmacogenetics and Genomics
Volume17
Issue number7
Pages (from-to)555-67
Number of pages13
ISSN1744-6872
DOIs
Publication statusPublished - 1 Jul 2007

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