Abstract
A series of dasatinib crystalline forms were obtained, and a hierarchical cluster analysis of their powder X-ray diffraction patterns was performed. The resulting dendrogram implies 3 structural groups. The crystal structures of several solvates representing 2 of these groups were determined. The crystal structure analysis confirms the isostructurality of solvates within structural group I and suggests a correlation between solvent molecule size and trends in crystal structures within this group. In addition, the formation relationships in 2-solvent media between different dasatinib solvate groups were determined. The formation preference of solvates was found to follow the ranking group I > group III > group II.
| Original language | English |
|---|---|
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 105 |
| Issue number | 4 |
| Pages (from-to) | 1489 - 1495 |
| ISSN | 0022-3549 |
| DOIs | |
| Publication status | Published - 2016 |
| Externally published | Yes |