TY - UNPB
T1 - Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS
AU - Mora, Santiago
AU - Friis, Rasmus von Huth
AU - Stuckert, Anna
AU - Noes-Holt, Gith
AU - Montañana-Rosell, Roser
AU - Sørensen, Andreas Toft
AU - Selvan, Raghavendra
AU - Allodi, Ilary
PY - 2022
Y1 - 2022
N2 - Loss of connectivity between spinal V1 inhibitory inter-neurons and motor neurons is found early in disease in the SOD1G93A ALS mice. Such changes in premotor inputs can contribute to homeostatic imbalance of vulnerable motor neurons. Here, we show, for the first time, that stabilization of V1 synapses by overexpression of the Extended Synap-totagmin 1 presynaptic organizer increases motor neuron survival and ameliorates motor phenotypes, demonstrating that interneurons can be a potential target to attenuate ALS symptoms
AB - Loss of connectivity between spinal V1 inhibitory inter-neurons and motor neurons is found early in disease in the SOD1G93A ALS mice. Such changes in premotor inputs can contribute to homeostatic imbalance of vulnerable motor neurons. Here, we show, for the first time, that stabilization of V1 synapses by overexpression of the Extended Synap-totagmin 1 presynaptic organizer increases motor neuron survival and ameliorates motor phenotypes, demonstrating that interneurons can be a potential target to attenuate ALS symptoms
U2 - 10.1101/2022.12.15.520568
DO - 10.1101/2022.12.15.520568
M3 - Preprint
T3 - bioRxiv
BT - Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS
ER -