Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema

J M Jungersted; H Scheer; M Mempel; H Baurecht; L Cifuentes; J K Høgh; Lars Hellgren; Gregor Jemec; T Agner; S Weidinger

doi:10.1111/j.1398-9995.2010.02326.x

Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema

J M Jungersted, H Scheer, M Mempel, H Baurecht, L Cifuentes, J K Høgh, Lars Hellgren, Gregor Jemec, T Agner, S Weidinger

Research output: Contribution to journal › Journal article › Research › peer-review

311 Citations (Scopus)

Abstract

Prior to the discovery of filaggrin (FLG) mutations, evidence for an impaired skin barrier in atopic dermatitis (AD) has been documented, and changes in ceramide profile, altered skin pH and increased trans-epidermal water loss (TEWL) in patients with AD have been reported. Until now, no studies have analysed stratum corneum (SC) lipids combined with skin barrier parameters in subjects of known FLG genotype.

Original language	English
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	65
Issue number	7
Pages (from-to)	911-8
Number of pages	8
ISSN	0105-4538
DOIs	https://doi.org/10.1111/j.1398-9995.2010.02326.x
Publication status	Published - 1 Jul 2010

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Jungersted, J. M., Scheer, H., Mempel, M., Baurecht, H., Cifuentes, L., Høgh, J. K., Hellgren, L., Jemec, G., Agner, T., & Weidinger, S. (2010). Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy: European Journal of Allergy and Clinical Immunology, 65(7), 911-8. https://doi.org/10.1111/j.1398-9995.2010.02326.x

Jungersted, JM, Scheer, H, Mempel, M, Baurecht, H, Cifuentes, L, Høgh, JK, Hellgren, L, Jemec, G, Agner, T & Weidinger, S 2010, 'Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema', Allergy: European Journal of Allergy and Clinical Immunology, vol. 65, no. 7, pp. 911-8. https://doi.org/10.1111/j.1398-9995.2010.02326.x

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AU - Baurecht, H

AU - Cifuentes, L

AU - Høgh, J K

AU - Hellgren, Lars

AU - Jemec, Gregor

AU - Agner, T

AU - Weidinger, S

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AB - Prior to the discovery of filaggrin (FLG) mutations, evidence for an impaired skin barrier in atopic dermatitis (AD) has been documented, and changes in ceramide profile, altered skin pH and increased trans-epidermal water loss (TEWL) in patients with AD have been reported. Until now, no studies have analysed stratum corneum (SC) lipids combined with skin barrier parameters in subjects of known FLG genotype.

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